LPAR3

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Lysophosphatidic acid receptor 3
Identifiers
Symbols LPAR3 ; EDG7; Edg-7; GPCR; HOFNH30; LP-A3; LPA3; RP4-678I3
External IDs OMIM605106 MGI1929469 HomoloGene8123 IUPHAR: LPA3 ChEMBL: 3250 GeneCards: LPAR3 Gene
RNA expression pattern
PBB GE EDG7 220816 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23566 65086
Ensembl ENSG00000171517 ENSMUSG00000036832
UniProt Q9UBY5 Q9EQ31
RefSeq (mRNA) NM_012152 NM_022983
RefSeq (protein) NP_036284 NP_075359
Location (UCSC) Chr 1:
85.28 – 85.36 Mb
Chr 3:
146.22 – 146.29 Mb
PubMed search [1] [2]

Lysophosphatidic acid receptor 3 also known as LPA3 is a protein that in humans is encoded by the LPAR3 gene.[1][2] LPA3 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[3]

Function[edit]

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.[1]

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: LPAR3 Lysophosphatidic acid receptor 3". 
  2. ^ Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Arai H, Inoue K (September 1999). "Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid". J. Biol. Chem. 274 (39): 27776–85. doi:10.1074/jbc.274.39.27776. PMID 10488122. 
  3. ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee C-W, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701. 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.