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Lysophosphatidic acid receptor 3
Symbols LPAR3 ; EDG7; Edg-7; GPCR; HOFNH30; LP-A3; LPA3; RP4-678I3
External IDs OMIM605106 MGI1929469 HomoloGene8123 IUPHAR: 274 ChEMBL: 3250 GeneCards: LPAR3 Gene
RNA expression pattern
PBB GE EDG7 220816 at tn.png
More reference expression data
Species Human Mouse
Entrez 23566 65086
Ensembl ENSG00000171517 ENSMUSG00000036832
UniProt Q9UBY5 Q9EQ31
RefSeq (mRNA) NM_012152 NM_022983
RefSeq (protein) NP_036284 NP_075359
Location (UCSC) Chr 1:
85.28 – 85.36 Mb
Chr 3:
146.22 – 146.29 Mb
PubMed search [1] [2]

Lysophosphatidic acid receptor 3 also known as LPA3 is a protein that in humans is encoded by the LPAR3 gene.[1][2] LPA3 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[3]


This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.[1]

See also[edit]


  1. ^ a b "Entrez Gene: LPAR3 Lysophosphatidic acid receptor 3". 
  2. ^ Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Arai H, Inoue K (September 1999). "Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid". J. Biol. Chem. 274 (39): 27776–85. doi:10.1074/jbc.274.39.27776. PMID 10488122. 
  3. ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee C-W, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.