LPAR5

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Lysophosphatidic acid receptor 5
Identifiers
Symbols LPAR5 ; GPR92; GPR93; KPG_010; LPA5
External IDs OMIM606926 MGI2685918 HomoloGene10696 IUPHAR: LPA5 ChEMBL: 5700 GeneCards: LPAR5 Gene
Orthologs
Species Human Mouse
Entrez 57121 381810
Ensembl ENSG00000184574 ENSMUSG00000067714
UniProt Q9H1C0 G3X9K0
RefSeq (mRNA) NM_001142961 NM_001163268
RefSeq (protein) NP_001136433 NP_001156740
Location (UCSC) Chr 12:
6.73 – 6.75 Mb
Chr 6:
125.07 – 125.08 Mb
PubMed search [1] [2]

Lysophosphatidic acid receptor 5 also known as LPA5 is a protein that in humans is encoded by the LPAR5 gene.[1][2][3][4][5] LPA5 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[6]

See also[edit]

References[edit]

  1. ^ Adhr, Consortium; Strom, Tim M.; White, Kenneth E.; Evans, Wayne E.; O'Riordan, Jeffery L.H.; Speer, Marcy C.; Lorenz-Depiereux, Bettina; Grabowski, Monika; Meitinger, Thomas (Dec 2000). "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23". Nat Genet 26 (3): 345–8. doi:10.1038/81664. PMID 11062477. 
  2. ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155. 
  3. ^ Lee CW, Rivera R, Gardell S, Dubin AE, Chun J (Aug 2006). "GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5". J Biol Chem 281 (33): 23589–97. doi:10.1074/jbc.M603670200. PMID 16774927. 
  4. ^ Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, Owman C, Sillard R, Leeb-Lundberg LM, Olde B (Jul 2006). "Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes". J Pharmacol Exp Ther 318 (2): 619–28. doi:10.1124/jpet.105.098848. PMID 16651401. 
  5. ^ "Entrez Gene: GPR92 G protein-coupled receptor 92". 
  6. ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee C-W, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701. 

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