Latrophilin-1 is a protein that in humans is encoded by the LPHN1gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane.
Nagase T, Ishikawa K, Suyama M et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res.5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID10048485.
Kreienkamp HJ, Zitzer H, Gundelfinger ED et al. (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". J. Biol. Chem.275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID10964907.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Brill LM, Salomon AR, Ficarro SB et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem.76 (10): 2763–72. doi:10.1021/ac035352d. PMID15144186.
Bjarnadóttir TK, Fredriksson R, Höglund PJ et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID15203201.