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Latrophilin 3
Symbols LPHN3 ; CIRL3; LEC3
External IDs MGI2441950 HomoloGene22878 IUPHAR: LPHN3 GeneCards: LPHN3 Gene
Species Human Mouse
Entrez 23284 319387
Ensembl ENSG00000150471 ENSMUSG00000037605
UniProt Q9HAR2 Q80TS3
RefSeq (mRNA) NM_015236 NM_198702
RefSeq (protein) NP_056051 NP_941991
Location (UCSC) Chr 4:
62.07 – 62.94 Mb
Chr 5:
81.02 – 81.83 Mb
PubMed search [1] [2]

Latrophilin-3 is a protein that in humans is encoded by the LPHN3 gene.[1][2]


This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.[2]

Clinical significance[edit]

A version of this gene has been linked to Attention Deficit/Hyperactivity Disorder (ADHD).[3]

See also[edit]


  1. ^ Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families". J Recept Signal Transduct Res 20 (2–3): 119–31. doi:10.3109/10799890009150640. PMID 10994649. 
  2. ^ a b "Entrez Gene: LPHN3 latrophilin 3". 
  3. ^ Arcos-Burgos M, Jain M, Acosta MT, et al. (November 2010). "A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication". Mol. Psychiatry 15 (11): 1053–66. doi:10.1038/mp.2010.6. PMID 20157310. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.