While LR-5182 itself never proceeded beyond initial animal studies, discovery of monoamine reuptake inhibition activity and stimulant effects in drugs of this type has subsequently led to the development of many other stimulant drugs of related chemical structure, primarily developed as potential antidepressants, or as substitute drugs for the treatment of cocaine abuse.
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^Fuller RW, Perry KW, Snoddy HD. In vivo effects of LR5182, cis-3-(3,4-dichlorophenyl)-2-N,N-dimethylaminomethyl-bicyclo-[2,2,2]-octane hydrochloride, an inhibitor of uptake into dopamine and norepinephrine neurons. Neuropharmacology. 1979, 18(5):497-501.
^Wong DT, Bymaster FP, Reid LR. Competitive inhibition of catecholamine uptake in synaptosomes of rat brain by rigid bicyclo-octanes. Journal of Neurochemistry. 1980 Jun;34(6):1453-8. PMID 7381469
^Wedney S, Howard JL, Large BT, Pullar IA. The inhibition of monoamine uptake into rat brain synaptosomes by selected bicyclo-octanes and an analogous bicyclo-octene. Biochemical Pharmacology. 1978, 27(24):2907-2909.
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^Deutsch HM, Collard DM, Zhang L, Burnham KS, Deshpande AK, Holtzman SG, Schweri MM. Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-(aminomethyl)-3-phenylbicyclo[2.2.2]- and -[2.2.1]alkane dopamine uptake inhibitors. Journal of Medicinal Chemistry. 1999 Mar 11;42(5):882-95. PMID 10072685
^Javanmard S, Deutsch HM, Collard DM, Kuhar MJ, Schweri MM. Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-substituted-6-amino-5-phenylbicyclo[2.2.2]octanes. Journal of Medicinal Chemistry. 1999 Nov 18;42(23):4836-43. PMID 10579846