LRIG1

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Leucine-rich repeats and immunoglobulin-like domains 1
Identifiers
Symbols LRIG1 ; LIG-1; LIG1
External IDs OMIM608868 MGI107935 HomoloGene7380 GeneCards: LRIG1 Gene
RNA expression pattern
PBB GE LRIG1 211596 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 26018 16206
Ensembl ENSG00000144749 ENSMUSG00000030029
UniProt Q96JA1 P70193
RefSeq (mRNA) NM_015541 NM_008377
RefSeq (protein) NP_056356 NP_032403
Location (UCSC) Chr 3:
66.43 – 66.55 Mb
Chr 6:
94.6 – 94.7 Mb
PubMed search [1] [2]

Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene.[1][2][3] It encodes a transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR-family[4] , MET[5] and RET.[6]

Model organisms[edit]

Model organisms have been used in the study of LRIG1 function. A conditional knockout mouse line, called Lrig1tm1a(EUCOMM)Wtsi[16][17] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[18][19][20]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[14][21] Twenty five tests were carried out on homozygous mutant mice and ten significant abnormalities were observed, including decreased body weight and total body fat, scaly skin, abnormal hair shedding, a moderate degree of hearing impairment, vertebral fusion, abnormal plasma chemistry and an increased susceptibility to bacterial infection (with both Salmonella and Citrobacter).[14]

References[edit]

  1. ^ Nilsson J, Vallbo C, Guo D, Golovleva I, Hallberg B, Henriksson R, Hedman H (Jun 2001). "Cloning, characterization, and expression of human LIG1". Biochem Biophys Res Commun 284 (5): 1155–61. doi:10.1006/bbrc.2001.5092. PMID 11414704. 
  2. ^ Hedman H, Nilsson J, Guo D, Henriksson R (Sep 2002). "Is LRIG1 a tumour suppressor gene at chromosome 3p14.3?". Acta Oncol 41 (4): 352–4. doi:10.1080/028418602760169398. PMID 12234026. 
  3. ^ "Entrez Gene: LRIG1 leucine-rich repeats and immunoglobulin-like domains 1". 
  4. ^ Gur G, Rubin C, Katz M et al. (2005). "LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation". EMBO J. 23 (16): 3270–81. doi:10.1038/sj.emboj.7600342. PMC 514515. PMID 15282549. 
  5. ^ Shattuck DL, Miller JK, Laederich M et al. (2007). "LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy". Mol. Cell. Biol. 27 (5): 1934–46. doi:10.1128/MCB.00757-06. PMC 1820466. PMID 17178829. 
  6. ^ Ledda F, Bieraugel O, Fard SS, Vilar M, Paratcha G. (2008). "Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF". J Neurosci. . 28 (2): 39–49. doi:10.1523/JNEUROSCI.2196-07.2008. PMID 18171921. 
  7. ^ "Body weight data for Lrig1". Wellcome Trust Sanger Institute. 
  8. ^ "Dysmorphology data for Lrig1". Wellcome Trust Sanger Institute. 
  9. ^ "DEXA data for Lrig1". Wellcome Trust Sanger Institute. 
  10. ^ "Radiography data for Lrig1". Wellcome Trust Sanger Institute. 
  11. ^ "Clinical chemistry data for Lrig1". Wellcome Trust Sanger Institute. 
  12. ^ "Salmonella infection data for Lrig1". Wellcome Trust Sanger Institute. 
  13. ^ "Citrobacter infection data for Lrig1". Wellcome Trust Sanger Institute. 
  14. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  15. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  16. ^ "International Knockout Mouse Consortium". 
  17. ^ "Mouse Genome Informatics". 
  18. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  19. ^ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  20. ^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  21. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 

Further reading[edit]