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Low density lipoprotein receptor-related protein 6
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LRP6 ; ADCAD2
External IDs OMIM603507 MGI1298218 HomoloGene1747 GeneCards: LRP6 Gene
RNA expression pattern
PBB GE LRP6 34697 at tn.png
PBB GE LRP6 205606 at tn.png
More reference expression data
Species Human Mouse
Entrez 4040 16974
Ensembl ENSG00000070018 ENSMUSG00000030201
UniProt O75581 O88572
RefSeq (mRNA) NM_002336 NM_008514
RefSeq (protein) NP_002327 NP_032540
Location (UCSC) Chr 12:
12.27 – 12.42 Mb
Chr 6:
134.45 – 134.57 Mb
PubMed search [1] [2]

Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene.[1][2]


LRP6 has been shown to interact with DKK1.[3]


  1. ^ Brown SD, Twells RC, Hey PJ, Cox RD, Levy ER, Soderman AR, Metzker ML, Caskey CT, Todd JA, Hess JF (Sep 1998). "Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family". Biochem Biophys Res Commun 248 (3): 879–88. doi:10.1006/bbrc.1998.9061. PMID 9704021. 
  2. ^ "Entrez Gene: LRP6 low density lipoprotein receptor-related protein 6". 
  3. ^ Semënov, M V; Tamai K; Brott B K; Kühl M; Sokol S; He X (Jun 2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol. (England) 11 (12): 951–61. doi:10.1016/S0960-9822(01)00290-1. ISSN 0960-9822. PMID 11448771. 

Further reading[edit]