LRRTM1

Leucine rich repeat transmembrane neuronal 1
Identifiers
Symbols	LRRTM1; FLJ32082
External IDs	OMIM: 610867 MGI: 2389173 HomoloGene: 41763 GeneCards: LRRTM1 Gene
Gene Ontology Molecular function • molecular_function Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • cell surface • membrane • integral to membrane • axon • growth cone Biological process • biological_process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	347730	74342
Ensembl	ENSG00000162951	ENSMUSG00000060780
UniProt	Q86UE6	Q8K377
RefSeq (mRNA)	NM_178839	NM_028880.3
RefSeq (protein)	NP_849161	NP_083156.2
Location (UCSC)	Chr 2: 80.52 – 80.53 Mb	Chr 6: 77.19 – 77.21 Mb
PubMed search	[1]	[2]

Leucine-rich repeat transmembrane neuronal protein 1 (LRRTM1) is a protein that in humans is encoded by the LRRTM1 gene.

LRRTM1 is the first gene linked to increased odds of being left-handed, at least if inherited from the father's side. Possessing one particular variant of the LRRTM1 gene slightly raises the risk of psychotic mental illnesses such as schizophrenia, again only if inherited from the father's side.

As the name implies, its protein product is a transmembrane protein that contains many leucine rich repeats and is present in neurons. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation (genomic imprinting).

See also

• Handedness

Further reading

• Siddiqui TJ, Pancaroglu R, Kang Y, Rooyakkers A, Craig AM (June 2010). "LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development". J. Neurosci. 30 (22): 7495–506. doi:10.1523/JNEUROSCI.0470-10.2010. PMID 20519524. 
• Sousa I, Clark TG, Holt R, et al. (2010). "Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry.". Mol Autism 1 (1): 7. doi:10.1186/2040-2392-1-7. PMC 2913944. PMID 20678249. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2913944. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Crow TJ, Close JP, Dagnall AM, Priddle TH (2009). "Where and what is the right shift factor or cerebral dominance gene? A critique of Francks et al. (2007).". Laterality 14 (1): 3–10. doi:10.1080/13576500802574984. PMID 19125366. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ludwig KU, Mattheisen M, Mühleisen TW, et al. (August 2009). "Supporting evidence for LRRTM1 imprinting effects in schizophrenia". Mol. Psychiatry 14 (8): 743–5. doi:10.1038/mp.2009.28. PMID 19626025. 
• McManus C, Nicholls M, Vallortigara G (2009). "Editorial commentary: is LRRTM1 the gene for handedness?". Laterality 14 (1): 1–2. doi:10.1080/13576500802542577. PMID 19125365. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Francks C (2009). "Understanding the genetics of behavioural and psychiatric traits will only be achieved through a realistic assessment of their complexity.". Laterality 14 (1): 11–6. doi:10.1080/13576500802536439. PMID 19125367.