LRRTM1

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Leucine rich repeat transmembrane neuronal 1
Identifiers
Symbols LRRTM1 ; FLJ32082
External IDs OMIM610867 MGI2389173 HomoloGene41763 GeneCards: LRRTM1 Gene
Orthologs
Species Human Mouse
Entrez 347730 74342
Ensembl ENSG00000162951 ENSMUSG00000060780
UniProt Q86UE6 Q8K377
RefSeq (mRNA) NM_178839 NM_028880
RefSeq (protein) NP_849161 NP_083156
Location (UCSC) Chr 2:
80.52 – 80.53 Mb
Chr 6:
77.24 – 77.26 Mb
PubMed search [1] [2]

LRRTM1 is a brain-expressed imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate synaptic cell adhesion in neurons.[1][2] As the name implies, its protein product is a transmembrane protein that contains many leucine rich repeats. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation (genomic imprinting).[3][4]

Clinical significance[edit]

LRRTM1 is the first gene linked to increased odds of being left-handed, when inherited from the father's side.[5] Possessing one particular variant of the LRRTM1 gene slightly raises the risk of psychotic mental illnesses such as schizophrenia, again only if inherited from the father's side.[5] As well, LRRTM1 has been associated with measures of schizotypy in non-clinical populations,[6] indicating that the gene may have shared effects on neurodevelopment in both healthy and healthy individuals and individuals with schizophrenia.

See also[edit]


References[edit]

  1. ^ Siddiqui TJ, Pancaroglu R, Kang Y, Rooyakkers A, Craig AM (Jun 2010). "LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development". The Journal of Neuroscience 30 (22): 7495–506. doi:10.1523/JNEUROSCI.0470-10.2010. PMC 2896269. PMID 20519524. 
  2. ^ Soler-Llavina GJ, Fuccillo MV, Ko J, Südhof TC, Malenka RC (Oct 2011). "The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo". Proceedings of the National Academy of Sciences 108 (40): 16502–16509. doi:10.1073/pnas.1114028108. PMID 21953696. 
  3. ^ "Entrez Gene: leucine rich repeat transmembrane neuronal 1". 
  4. ^ Laurén J, Airaksinen MS, Saarma M, Timmusk T (April 2003). "A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system". Genomics 81 (4): 411–21. doi:10.1016/S0888-7543(03)00030-2. PMID 12676565. 
  5. ^ a b Francks C, Maegawa S, Laurén J, Abrahams BS, Velayos-Baeza A, Medland SE, Colella S, Groszer M, McAuley EZ, Caffrey TM, Timmusk T, Pruunsild P, Koppel I, Lind PA, Matsumoto-Itaba N, Nicod J, Xiong L, Joober R, Enard W, Krinsky B, Nanba E, Richardson AJ, Riley BP, Martin NG, Strittmatter SM, Möller HJ, Rujescu D, St Clair D, Muglia P, Roos JL, Fisher SE, Wade-Martins R, Rouleau GA, Stein JF, Karayiorgou M, Geschwind DH, Ragoussis J, Kendler KS, Airaksinen MS, Oshimura M, DeLisi LE, Monaco AP (December 2007). "LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia". Mol. Psychiatry 12 (12): 1129–39, 1057. doi:10.1038/sj.mp.4002053. PMC 2990633. PMID 17667961. Lay summaryBBC News. 
  6. ^ Leach EL, Prefontaine G, Hurd PL, Crespi BJ (Jun 2014). "The imprinted gene LRRTM1 mediates schizotypy and handedness in a nonclinical population". Journal of Human Genetics 59 (6): 332–336. doi:10.1038/jhg.2014.30. PMID 24785688. 

Further reading[edit]