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Leucine rich repeat transmembrane neuronal 1
Symbols LRRTM1 ; FLJ32082
External IDs OMIM610867 MGI2389173 HomoloGene41763 GeneCards: LRRTM1 Gene
Species Human Mouse
Entrez 347730 74342
Ensembl ENSG00000162951 ENSMUSG00000060780
UniProt Q86UE6 Q8K377
RefSeq (mRNA) NM_178839 NM_028880
RefSeq (protein) NP_849161 NP_083156
Location (UCSC) Chr 2:
80.52 – 80.53 Mb
Chr 6:
77.24 – 77.26 Mb
PubMed search [1] [2]

Leucine-rich repeat transmembrane neuronal protein 1 (LRRTM1) is a protein that in humans is encoded by the LRRTM1 gene.[1][2]

LRRTM1 is the first gene linked to increased odds of being left-handed, at least if inherited from the father's side.[3] Possessing one particular variant of the LRRTM1 gene slightly raises the risk of psychotic mental illnesses such as schizophrenia, again only if inherited from the father's side.[3]

As the name implies, its protein product is a transmembrane protein that contains many leucine rich repeats and is present in neurons. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation (genomic imprinting).[2]

See also[edit]


  1. ^ "Entrez Gene: leucine rich repeat transmembrane neuronal 1". 
  2. ^ a b Laurén J, Airaksinen MS, Saarma M, Timmusk T (April 2003). "A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system". Genomics 81 (4): 411–21. doi:10.1016/S0888-7543(03)00030-2. PMID 12676565. 
  3. ^ a b Francks C, Maegawa S, Laurén J, et al. (December 2007). "LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia". Mol. Psychiatry 12 (12): 1129–39, 1057. doi:10.1038/ PMC 2990633. PMID 17667961. Lay summaryBBC News. 

Further reading[edit]