LTBP2

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Latent transforming growth factor beta binding protein 2
Identifiers
Symbols LTBP2 ; C14orf141; GLC3D; LTBP3; MSPKA; MSTP031; WMS3
External IDs OMIM602091 MGI99502 HomoloGene369 GeneCards: LTBP2 Gene
RNA expression pattern
PBB GE LTBP2 204682 at tn.png
PBB GE LTBP2 gnf1h00588 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4053 16997
Ensembl ENSG00000119681 ENSMUSG00000002020
UniProt Q14767 O08999
RefSeq (mRNA) NM_000428 NM_013589
RefSeq (protein) NP_000419 NP_038617
Location (UCSC) Chr 14:
74.96 – 75.08 Mb
Chr 12:
84.78 – 84.88 Mb
PubMed search [1] [2]

Latent-transforming growth factor beta-binding protein 2 is a protein that in humans is encoded by the LTBP2 gene.[1][2]

The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.[2]

References[edit]

  1. ^ Moren A, Olofsson A, Stenman G, Sahlin P, Kanzaki T, Claesson-Welsh L, ten Dijke P, Miyazono K, Heldin CH (Jan 1995). "Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein". J Biol Chem 269 (51): 32469–78. PMID 7798248. 
  2. ^ a b "Entrez Gene: LTBP2 latent transforming growth factor beta binding protein 2". 

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