LUM

Lumican
Identifiers
Symbols	LUM; LDC; SLRR2D
External IDs	OMIM: 600616 MGI: 109347 HomoloGene: 37614 GeneCards: LUM Gene
Gene Ontology Molecular function • extracellular matrix structural constituent • collagen binding Cellular component • extracellular region • proteinaceous extracellular matrix • fibrillar collagen • extracellular space • extracellular matrix Biological process • visual perception • response to organic cyclic compound • collagen fibril organization • cartilage development • response to growth factor stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4060	17022
Ensembl	ENSG00000139329	ENSMUSG00000036446
UniProt	P51884	P51885
RefSeq (mRNA)	NM_002345	NM_008524.2
RefSeq (protein)	NP_002336	NP_032550.2
Location (UCSC)	Chr 12: 91.5 – 91.51 Mb	Chr 10: 97.03 – 97.04 Mb
PubMed search	[1]	[2]

Lumican, also known as LUM, is a protein which in humans is encoded by the LUM gene.

Function

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.

Further reading

• Chakravarti S, Stallings RL, SundarRaj N, et al. (1995). "Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22.". Genomics 27 (3): 481–8. doi:10.1006/geno.1995.1080. PMID 7558030. 
• Grover J, Chen XN, Korenberg JR, Roughley PJ (1995). "The human lumican gene. Organization, chromosomal location, and expression in articular cartilage.". J. Biol. Chem. 270 (37): 21942–9. doi:10.1074/jbc.270.37.21942. PMID 7665616. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Rada JA, Cornuet PK, Hassell JR (1996). "Regulation of corneal collagen fibrillogenesis in vitro by corneal proteoglycan (lumican and decorin) core proteins.". Exp. Eye Res. 56 (6): 635–48. doi:10.1006/exer.1993.1081. PMID 8595806. 
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Matsushima N, Ohyanagi T, Tanaka T, Kretsinger RH (2000). "Super-motifs and evolution of tandem leucine-rich repeats within the small proteoglycans--biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin.". Proteins 38 (2): 210–25. doi:10.1002/(SICI)1097-0134(20000201)38:2<210::AID-PROT9>3.0.CO;2-1. PMID 10656267. 
• Svensson L, Närlid I, Oldberg A (2000). "Fibromodulin and lumican bind to the same region on collagen type I fibrils.". FEBS Lett. 470 (2): 178–82. doi:10.1016/S0014-5793(00)01314-4. PMID 10734230. 
• Pellegata NS, Dieguez-Lucena JL, Joensuu T, et al. (2000). "Mutations in KERA, encoding keratocan, cause cornea plana.". Nat. Genet. 25 (1): 91–5. doi:10.1038/75664. PMID 10802664. 
• Neame PJ, Kay CJ, McQuillan DJ, et al. (2000). "Independent modulation of collagen fibrillogenesis by decorin and lumican.". Cell. Mol. Life Sci. 57 (5): 859–63. doi:10.1007/s000180050048. PMID 10892350. 
• Grover J, Liu CY, Kao WW, Roughley PJ (2001). "Analysis of the human lumican gene promoter.". J. Biol. Chem. 275 (52): 40967–73. doi:10.1074/jbc.M004134200. PMID 11016924. 
• Naito Z, Ishiwata T, Kurban G, et al. (2002). "Expression and accumulation of lumican protein in uterine cervical cancer cells at the periphery of cancer nests.". Int. J. Oncol. 20 (5): 943–8. PMID 11956587. 
• Lu YP, Ishiwata T, Kawahara K, et al. (2003). "Expression of lumican in human colorectal cancer cells.". Pathol. Int. 52 (8): 519–26. doi:10.1046/j.1440-1827.2002.01384.x. PMID 12366811. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574. 
• Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.". Proteomics 4 (2): 454–65. doi:10.1002/pmic.200300556. PMID 14760718. 
• Botella LM, Sanz-Rodriguez F, Sanchez-Elsner T, et al. (2004). "Lumican is down-regulated in cells expressing endoglin. Evidence for an inverse correlationship between Endoglin and Lumican expression.". Matrix Biol. 22 (7): 561–72. doi:10.1016/j.matbio.2003.11.006. PMID 14996436. 
• Vuillermoz B, Khoruzhenko A, D'Onofrio MF, et al. (2004). "The small leucine-rich proteoglycan lumican inhibits melanoma progression.". Exp. Cell Res. 296 (2): 294–306. doi:10.1016/j.yexcr.2004.02.005. PMID 15149859. 
• Köninger J, Giese T, di Mola FF, et al. (2004). "Pancreatic tumor cells influence the composition of the extracellular matrix.". Biochem. Biophys. Res. Commun. 322 (3): 943–9. doi:10.1016/j.bbrc.2004.08.008. PMID 15336555. 
• Li Y, Aoki T, Mori Y, et al. (2004). "Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell colony formation in soft agar.". Cancer Res. 64 (19): 7058–64. doi:10.1158/0008-5472.CAN-04-1038. PMID 15466200.