Ly6/neurotoxin 1 is a protein in humans that is encoded by the LYNX1 gene. [1 ] Alternatively spliced variants encoding different isoforms have been identified.
Function [ edit ]
This gene encodes a member of the Ly-6/
neurotoxin gene family, a group of lymphocyte antigens that attach to the cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine residues with a characteristic spacing pattern. Functional analysis indicates that this protein is not a ligand or neurotransmitter but has the capacity to enhance nicotinic acetylcholine receptor function in the presence of acetylcholine. This gene may also play a role in the pathogenesis of psoriasis vulgaris. [1 ]
The LYNX1 gene codes for a protein (Lynx1) that binds to
acetylcholine receptors in the brain. Lynx1 a member of the Ly6 superfamily of proteins that are capable of modulating neurotransmitter receptors. [2 ] [3 ] Transgenic mice without Lynx1 expression do not have a normal critical period of neuroplasticity in the visual cortex for development of ocular dominance columns. These mice show unusually rapid recovery from [4 ] amblyopia in adulthood indicating a role in reduction of synaptic plasticity during the normal expression of Lynx1 in adult brain. [2 ]
See also [ edit ]
Other Ly6 family proteins that are expressed in the brain:
Lynx2, LYPD6, LYPD6B and PSCA. [2 ]
References [ edit ]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.