LYNX1

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Ly6/neurotoxin 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols LYNX1 ; SLURP2
External IDs OMIM606110 HomoloGene8026 GeneCards: LYNX1 Gene
Orthologs
Species Human Mouse
Entrez 66004 23936
Ensembl ENSG00000180155 ENSMUSG00000022594
UniProt Q9BZG9 Q9WVC2
RefSeq (mRNA) NM_023946 NM_011838
RefSeq (protein) NP_076435 NP_035968
Location (UCSC) Chr 8:
143.85 – 143.86 Mb
Chr 15:
74.75 – 74.75 Mb
PubMed search [1] [2]

Ly6/neurotoxin 1 is a protein in humans that is encoded by the LYNX1 gene.[1] Alternatively spliced variants encoding different isoforms have been identified.

Function[edit]

This gene encodes a member of the Ly-6/neurotoxin gene family, a group of lymphocyte antigens that attach to the cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine residues with a characteristic spacing pattern. Functional analysis indicates that this protein is not a ligand or neurotransmitter but has the capacity to enhance nicotinic acetylcholine receptor function in the presence of acetylcholine. This gene may also play a role in the pathogenesis of psoriasis vulgaris.[1]

The LYNX1 gene codes for a protein (Lynx1) that binds to acetylcholine receptors in the brain.[2] Lynx1 a member of the Ly6 superfamily of proteins that are capable of modulating neurotransmitter receptors.[3] Transgenic mice without Lynx1 expression do not have a normal critical period of neuroplasticity in the visual cortex for development of ocular dominance columns.[4] These mice show unusually rapid recovery from amblyopia in adulthood indicating a role in reduction of synaptic plasticity during the normal expression of Lynx1 in adult brain.[2]

See also[edit]

Other Ly6 family proteins that are expressed in the brain: Lynx2, LYPD6, LYPD6B and PSCA.[2]

References[edit]

  1. ^ a b "Entrez Gene: Ly6/neurotoxin 1". 
  2. ^ a b c Miwa JM, Lester HA, Walz A (August 2012). "Optimizing cholinergic tone through lynx modulators of nicotinic receptors: implications for plasticity and nicotine addiction". Physiology (Bethesda) 27 (4): 187–99. doi:10.1152/physiol.00002.2012. PMID 22875450. 
  3. ^ Holford M, Auer S, Laqua M, Ibañez-Tallon I (2009). "Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulators". Front Mol Neurosci 2: 21. doi:10.3389/neuro.02.021.2009. PMC 2776481. PMID 19915728. 
  4. ^ Higley MJ, Strittmatter SM (November 2010). "Neuroscience. Lynx for braking plasticity". Science 330 (6008): 1189–90. doi:10.1126/science.1198983. PMC 3244692. PMID 21109660. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.