In historic times before the arrival of the Spaniards, Acentejo was part of the menceyato (kingdom) of Taoro. The first and the second battles of Acentejo took place in 1494. The Spanish under Alonso Fernández de Lugo suffered a terrible defeat at this first battle, at the place now called La Matanza ("The Slaughter"). It occurred in present-day Barranco de San Antonio, which the Guanches called Farfan. The second battle resulted in a victory for the Spaniards, in which the town of La Victoria de Acentejo was founded.
Currently under construction is a scale replica of the interior of the Holy Sepulchre in Jerusalem (the place where according to Christian tradition, was taken the body of Jesus Christ after his crucifixion), the replica will be located in the plaza of El Salvador's municipality. In this room is to also place a replica of the Shroud of Turin (Italy).