The football program existed from 1931-1941, until the start of World War II. The war reduced the amount of male students at the university, so the football program ended in 1941. It was revived in 1997 and joined the MAAC football league in 1999.
At the end of the 2007 Football season, in which the team finished 0-10, it was announced that La Salle would again be discontinuing the Football program. The MAAC football league also dissolved soon thereafter. 
In November 2009, the university settled a $7.5 million lawsuit with a football player who suffered a severe brain injury in a 2005 game.