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Lability refers to something that is constantly undergoing change or something that is likely to undergo change.
The term is used to describe a transient chemical species. As a general example, if a molecule exists in a particular conformation for a short life-time, before adopting a lower energy conformation, the former molecular structure is said to have 'high lability' (such as C25, a 25-carbon fullerene spheroid). The term is sometimes also used in reference to reactivity - for example, a complex that quickly reaches equilibrium in solution is said to be labile (with respect to that solution). Another common example is the cis effect in organometallic chemistry, which is the labilization of CO ligands in the cis position of octahedral transition metal complexes.
In reference to biochemistry, this is an important concept as far as kinetics is concerned in metalloproteins. This can allow for the rapid synthesis and degradation of substrates in biological systems.
In medicine, the term "labile" means susceptible to alteration or destruction. For example, a heat-labile protein is one that can be changed or destroyed at high temperatures.
The opposite of labile in this context is "stable."
- "Regeneration and Repair".
- Jackson CJ, Fox AJ, Jones DM, Wareing DR, Hutchinson DN (August 1998). "Associations between heat-stable (O) and heat-labile (HL) serogroup antigens of Campylobacter jejuni: evidence for interstrain relationships within three O/HL serovars". Journal of clinical microbiology 36 (8): 2223–8. PMC 105019. PMID 9665996.
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