One story about the name is that a tribe of Comanche Indians, led by their chief Lacassine, migrated to southwest Louisiana to hunt and fish in the early 19th century, settling near this place.
Another states this part of the parish was visited regularly by different tribes of the area, including Attakapas and Choctaw. Game was abundant here, and the Indians called it their "hunting ground," or, in the Choctaw language, La Cassine. However, the phrase sounds more French than Indian. La Cassine means "the small house" in French. According to Monsignor Jules Daigle, noted authority of the Cajun language, it was named for a small house built by an Indian chief in that location.