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CAS number 1891-29-8 YesY
PubChem 821383
ChemSpider 717609 N
KEGG C09489 N
Jmol-3D images Image 1
Molecular formula C15H16O5
Molar mass 276.28 g/mol
Appearance White crystalline solid
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Lactucin is a bitter substance that forms a white crystalline solid and belongs to the group of sesquiterpene lactones. It is found in some varieties of lettuce and is an ingredient of lactucarium. It has been shown to have analgesic and sedative properties.[1] It has also shown some antimalarial effects.[2] It is also found in dandelion coffee.

It acts as adenosine receptor agonist.[citation needed]

See also[edit]


  1. ^ Wesołowska A, Nikiforuk A, Michalska K, Kisiel W, Chojnacka-Wójcik E (2006). "Analgesic and Sedative Activities of Lactucin and some Lactucin-Like Guaianolides in Mice". Journal of Ethnopharmacology 107 (2): 254–258. doi:10.1016/j.jep.2006.03.003. PMID 16621374. 
  2. ^ Bischoff TA, Kelley CJ, Karchesy Y, Laurantos M, Nguyen-Dinh P, Arefi AG (2004). "Antimalarial Activity of Lactucin and Lactucopicrin: Sesquiterpene Lactones Isolated from Cichorium intybus L.". Journal of Ethnopharmacology 95 (2–3): 455–457. doi:10.1016/j.jep.2004.06.031. PMID 15507374.