When Liu Bei visited Yu Province, he stayed in Xiaopei (小沛; present-day Pei County, Xuzhou, Jiangsu), where he met Lady Gan and took her as his concubine. She followed Liu Bei to Jing Province later, where she gave birth to Liu Shan. During the Battle of Changban, Liu Bei fled and abandoned her and Liu Shan, but she and her son were both saved by Zhao Yun. She was buried in Nan Commandery (南郡; around present-day Jingzhou, Hubei) after her death.
In 221, after Liu Bei proclaimed himself "Emperor of Shu Han", he granted Lady Gan the posthumous title of "Lady Huangsi" (皇思夫人), which literally means "the Lady whom the Emperor missed". Lady Gan's remains were excavated from Nan Commandery for reburial in Shu (present-day Sichuan), but Liu Bei died before this was completed.
Later, after Liu Shan succeeded his father Liu Bei as emperor of Shu, Zhuge Liang wrote a memorial to Liu Shan, suggesting that Lady Gan be honoured and buried together with Liu Bei. Liu Shan obliged and granted his mother the posthumous title of "Empress Zhaolie" (昭烈皇后) to match his father's posthumous title of "Emperor Zhaolie".
- de Crespigny, Rafe (2007). A biographical dictionary of Later Han to the Three Kingdoms (23–220 AD). Brill. p. 238. ISBN 978-90-04-15605-0.
- (先主甘皇后，沛人也。) Chen Shou. Records of the Three Kingdoms, Volume 34, Biography of Lady Gan.
- (先主臨豫州，住小沛，納以為妄。先主數喪嫡室，常攝內事。隨先主於荊州，產後主。值曹公軍至，追及先主於當陽長阪，於時困偪，棄後及後主，賴趙雲保護，得免於難。後卒，葬於南郡。) Chen Shou. Records of the Three Kingdoms, Volume 34, Biography of Lady Gan.
- (章武二年，追諡皇思夫人，遷葬於蜀，未至而先主殂隕。) Chen Shou. Records of the Three Kingdoms, Volume 34, Biography of Lady Gan.
- (丞相亮上言：「皇思夫人履行脩仁，淑慎其身。大行皇帝昔在上將，嬪妃作合，載育聖躬，大命不融。大行皇帝存時，篤義垂恩，念皇思夫人神柩在遠飄颻，特遣使者奉迎。會大行皇帝崩，今皇思夫人神柩以到，又梓宮在道，園陵將成，安厝有期。臣輒與太常臣賴恭等議：禮記曰：『立愛自親始，教民孝也；立敬自長始，教民順也。』不忘其親，所由生也。春秋之義，母以子貴。昔高皇帝追尊太上昭靈夫人為昭靈皇后，孝和皇帝改葬其母梁貴人，尊號曰恭懷皇后，孝愍皇帝亦改葬其母王夫人，尊號曰靈懷皇后。今皇思夫人宜有尊號，以慰寒泉之思，輒與恭等案諡法，宜曰昭烈皇后。詩曰：『谷則異室，死則同穴。』禮云：上古無合葬，中古後因時方有。故昭烈皇后宜與大行皇帝合葬，臣請太尉告宗廟，布露天下，具禮儀別奏。」制曰可。) Chen Shou. Records of the Three Kingdoms, Volume 34, Biography of Lady Gan.