Lalou established herself as a businesswoman in the Burgundy wine business in 1955, when she took over her father Henri Leroy's (1894–1980) négociant business. From 1974, she was co-managing the Burgundy winery Domaine de la Romanée-Conti (DRC), one of the world's top wine estates, and was in charge of marketing. Along with Aubert de Villaine, Bize-Leroy helped build DRC's top wine Romanée-Conti into one of the most sought after wines in the world. A series of disagreements, including Bize-Leroy's displeasure at de Villaine's involvement in the Judgment of Paris wine tasting and disputes over Bize-Leroy's handling of the distribution of the Domaine's wines, led to her being ousted in 1992.
After leaving DRC, she has focused on her own domains. Already in 1988, she had acquired significant vineyard holdings for Domaine Leroy. During the 1990s, she established Domaine Leroy as one of the leading Burgundy wineries.
Lalou Bize-Leroy is a strong believer in biodynamic wine production, and practices it in her domaines.
- Clive Coates (1997): Côte d'Or: a celebration of the great wines of Burgundy, p. 528
- Neal Martin: Producer Profile: Domaine Leroy, Wine Journal
- G. Taber The Judgment of Paris: California vs France pg 217 Simon & Schuster ISBN 0-7432-4751-5
- Per-Henrik Mansson La Grande Leroy Wine Spectator December 15, 1996