Lanatoside C

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"Cedilanid" redirects here. It is not to be confused with Cedilanide, a trade name of deslanoside.
Lanatoside C
Lanatoside C.svg
Systematic (IUPAC) name
(3β,5β,12β)- 3-{[β-D- glucopyranosyl- (1→4)- 3-O-acetyl- 2,6-dideoxy- β-D-ribo- hexopyranosyl- (1→4)- 2,6-dideoxy- β-D- ribo- hexopyranosyl- (1→4)- 2,6-dideoxy- β-D- ribo- hexopyranosyl]oxy}- 12,14-dihydroxycard- 20(22)- enolide
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
?
Routes Oral, intravenous
Identifiers
CAS number 17575-22-3 YesY
ATC code C01AA06
PubChem CID 656630
ChemSpider 570984 YesY
UNII 5RR3JFZ771 YesY
KEGG D01972 YesY
ChEMBL CHEMBL506569 YesY
Synonyms [6-[6-[6-[[12,14-dihydroxy- 10,13-dimethyl- 17-(5-oxo-2H-furan-3-yl)- 1,2,3,4,5,6,7,8,9,11,12,15,16,17- tetradecahydrocyclopenta[a]phenanthren- 3-yl]oxy]- 4-hydroxy- 2-methyloxan- 3-yl]oxy- 4-hydroxy- 2-methyloxan-3-yl]oxy- 2-methyl- 3-[3,4,5-trihydroxy- 6-(hydroxymethyl)oxan-2-yl]oxyoxan- 4-yl] acetate
Chemical data
Formula C49H76O20 
Mol. mass 985.116 g/mol
 YesY (what is this?)  (verify)

Lanatoside C (or isolanid) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). Lanatoside C can be used orally[1] or by the intravenous route.[2] It is marketed in a number of countries and is also available in generic form.[3] Its main indications are rapid response atrial fibrilation and paroxysmal supraventricular tachycardia,[citation needed] two common types of arrhythmia.

It is found in Digitalis lanata.[4]

Chemistry[edit]

The substance is composed of four monosaccharides (glucose, 3-acetyldigitoxose and two digitoxoses) and an aglycon named digoxigenin.[5]

References[edit]

  1. ^ Lypka, A.; Lazowski, J. (1979). "(title in Polish)" [Comparative study of blood serum concentrations of digoxin and lanatoside C after single oral administration]. Wiadomości Lekarskie (in Polish) (Warsaw, Poland) 32 (18): 1277–1281. PMID 506267.  edit
  2. ^ Tàmmaro, A. E.; Baldoli, C. (1967). "On some immediate effects of the intravenous administration of desacetyl-lanatoside C in aged subjects" [On some immediate effects of the intravenous administration of desacetyl-lanatoside C in aged subjects]. La Clinica Terapeutica (in Italian) 40 (2): 157–161. PMID 5600177.  edit
  3. ^ "Lanatoside C". International Drug Names. Drugs.com. 
  4. ^ Determination of Lanatoside C and Digoxin in Digitalis lanata by Hplc and Its Application to Analysis of the Fermented Leaf Powder. Yukari Ikeda, Youichi Fujii and Mitsuru Yamazaki, J. Nat. Prod., 1992, volume 55, issue 6, pages 748–752, doi:10.1021/np50084a007
  5. ^ Desai, U. R. (2005). "Cardiac Glycosides". VCU School of Pharmacy.