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Greene appeared in John Wells' film The Company Men opposite Ben Affleck and Tommy Lee Jones. He starred as Billy O’Toole in On Broadway, an independent film shot in Boston, acting opposite Mike O’Malley, Joey McInytyre, Eliza Dushku, Will Arnett and Amy Poehler. He appeared in Southie and War of Chinas Fate, a World War II film shot on location in China. He played troubled twin brothers Aidan and Terry O’Toole in Back to Before by On Broadway writer/director Dave McLaughlin at the Boston Center for the Arts with Robert Wahlberg. He acted in the original theater production of God Willing at The Burren in Davis Square, Somerville, MA, and later produced this play in New York City. Greene was the lead in the short film Killing Time and played a Harvard Graduate trapped in a cab with a person he put behind bars in the short film Downtown produced by Ed Burns.
- "Local actor Lance Greene gets hairy, raises money". The Boston Globe. November 28, 2011. Retrieved December 3, 2014.
- "'On Broadway' filming set to begin". The Boston Globe. April 19, 2006. Retrieved February 26, 2010.
- Dezell, Maureen (December 14, 2003). "Playwright tells stories for his own audience". The Boston Globe. Retrieved February 26, 2010.