Langerin

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CD207 molecule, langerin
Protein CD207 PDB 3C22.png
Rendering based on PDB 3C22.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CD207 ; CLEC4K
External IDs OMIM604862 MGI2180021 HomoloGene9252 GeneCards: CD207 Gene
RNA expression pattern
PBB GE CD207 220428 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 50489 246278
Ensembl ENSG00000116031 ENSMUSG00000034783
UniProt Q9UJ71 Q8VBX4
RefSeq (mRNA) NM_015717 NM_144943
RefSeq (protein) NP_056532 NP_659192
Location (UCSC) Chr 2:
71.06 – 71.06 Mb
Chr 6:
83.67 – 83.68 Mb
PubMed search [1] [2]

CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the CD207 gene.[1][2] Langerin is a type II transmembrane, C-type lectin receptor on Langerhans cells.[2][3]

Function[edit]

The protein encoded by this gene is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Additionally its known by the name C-type lectin domain family 4 member K (CD antigen CD207). It is also expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway.[1]

Clinical significance[edit]

Langerin on mucosal Langerhans cells of the human genital epithelium binds to HIV-1 and subsequently internalizes it into Birbeck granules to be degraded.[4][5]

See also[edit]

References[edit]

  1. ^ a b EntrezGene 50489
  2. ^ a b Valladeau J, Ravel O, Dezutter-Dambuyant C, Moore K, Kleijmeer M, Liu Y, Duvert-Frances Vé, Vincent C, Schmitt D (2000). "Langerin, a Novel C-Type Lectin Specific to Langerhans Cells, is an Endocytic Receptor that Induces the Formation of Birbeck Granules". Immunity 12 (1): 71–81. doi:10.1016/S1074-7613(00)80160-0. PMID 10661407. 
  3. ^ Valladeau J, Clair-Moninot Vé, Dezutter-Dambuyant C, Pin J-J, Kissenpfennig A, Mattéi M-G, Ait-Yahia S, Bates EEM, Malissen B (2002). "Identification of Mouse Langerin/CD207 in Langerhans Cells and Some Dendritic Cells of Lymphoid Tissues". Journal of Immunology 168 (2): 782–92. doi:10.4049/jimmunol.168.2.782. PMID 11777972. 
  4. ^ De Witte L, Nabatov A, Pion M, Fluitsma D, De Jong MAWP, De Gruijl T, Piguet V, Van Kooyk Y, Geijtenbeek TBH (2007). "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells". Nature Medicine 13 (3): 367–71. doi:10.1038/nm1541. PMID 17334373. 
  5. ^ Turville S, Wilkinson J, Cameron P, Dable J, Cunningham AL (2003). "The role of dendritic cell C-type lectin receptors in HIV pathogenesis". Journal of Leukocyte Biology 74 (5): 710–8. doi:10.1189/jlb.0503208. PMID 12960229. 


Further reading[edit]

External links[edit]