Lanosterol 14 α-demethylase (or CYP51A1, P45014DM) is a cytochrome P450 (family 51, subfamily A, polypeptide 1) enzyme that converts lanosterol to cholesterol.
It is a target for antifungal drugs, inhibiting the production of ergosterol. Over-expression of CYP51A1 can lead to resistance to these antifungals.[1]
[edit] See also
[edit] References
- ^ Vanden Bossche H, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D (1998). "Antifungal drug resistance in pathogenic fungi". Med. Mycol. 36 Suppl 1: 119–28. PMID 9988500.
[edit] External links
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| CYP1 |
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| CYP2 |
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| CYP3 (CYP3A) |
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| CYP4 |
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| CYP5-20 |
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| CYP21-51 |
CYP21 ( A2) · CYP24 ( A1) · CYP26 ( A1, B1, C1) · CYP27 ( A1, B1, C1) · CYP39 ( A1) · CYP46 ( A1) · CYP51 ( A1)
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