Larock indole synthesis
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The Larock indole synthesis is a chemical reaction used to synthesize indoles from ortho-iodoanilines and a disubstituted alkyne.
An excess of alkyne, using palladium carbonate or palladium acetate and a base, and adding one equivalent of lithium chloride tend to give the best yields. Many functional groups are tolerated on the aniline and the alkyne.
Regarding the regioselectivity of the internal alkyne, the R-group with the largest steric bulk will end up in the R2 position.
[edit] References
- Larock, R.C.; Yum, E. K.; Refvik, M. D.; J. Org. Chem. 1998, 63, 7652.
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