Last universal ancestor

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For lowest common ancestors in graph theory and computer science, see lowest common ancestor.
"LUCA" redirects here. For other uses, see Luca (disambiguation).
A cladogram linking all major groups of living organisms to the LUA (the black trunk at the bottom). This graph is derived from ribosomal RNA sequence data.[1]
A cladogram linking all major groups of living organisms to the LUA (short trunk at the center). This graph is derived from complete genome sequencing data.

The last universal ancestor (LUA), also called the last universal common ancestor (LUCA), cenancestor, or progenote, is the most recent organism from which all organisms now living on Earth descend.[2] Thus it is the most recent common ancestor (MRCA) of all current life on Earth. The LUA is estimated to have lived some 3.5 to 3.8 billion years ago (sometime in the Paleoarchean era).[3][4] The earliest evidences for life on Earth are graphite found to be biogenic in 3.7 billion-year-old metasedimentary rocks discovered in Western Greenland[5] and microbial mat fossils found in 3.48 billion-year-old sandstone discovered in Western Australia.[6][7]

Charles Darwin proposed the theory of universal common descent through an evolutionary process in his book On the Origin of Species, saying, "Therefore I should infer from analogy that probably all the organic beings which have ever lived on this earth have descended from some one primordial form, into which life was first breathed."[8]

Features[edit]

Considering what we know of the offspring groups (see phylogenetic bracketing), the LUA was a small, single-cell organism. It would have had a cell wall and a ring-shaped coil of DNA floating freely within the cell, like modern bacteria. It would likely not have stood out against a collection of modern generalized small size bacteria.

While the gross anatomy must be reconstructed with some uncertainty, the internal mechanisms can be described in some detail, based on the properties currently shared by all independently living organisms on Earth:[9][10][11][12]

  • The genetic code was based on DNA. Note, however, that other studies suggest that LUCA may have lacked DNA and been defined wholly through RNA [13]
  • The genetic code was expressed via RNA intermediates, which were single-strand.
    • RNA was produced by a DNA-dependent RNA polymerase using nucleotides similar to those of DNA with the exception that thymidine in DNA was replaced by uridine in RNA.
  • The genetic code was expressed into proteins.
  • Proteins were assembled from free amino acids by translation of an mRNA by ribosomes, tRNA and a group of related proteins.
    • Ribosomes were composed of two subunits, one big 50S and one small 30S.
    • Each ribosomal subunit was composed of a core of ribosomal RNA surrounded by ribosomal proteins.
    • The RNA molecules (rRNA and tRNA) played an important role in the catalytic activity of the ribosomes.
    • Only 20 amino acids were used, to the exclusion of countless other amino acids.
    • Only the L-isomers of the amino acids were used.
  • ATP was used as an energy intermediate.
  • There were several hundred protein enzymes that catalyzed chemical reactions that extract energy from fats, sugars, and amino acids, and that synthesize fats, sugars, amino acids, and nucleic acid bases using arbitrary chemical pathways.
  • The cell contained a water-based cytoplasm that was surrounded and effectively enclosed by a lipid bilayer membrane.
  • Inside the cell, the concentration of sodium was lower, and potassium was higher, than outside. This gradient was maintained by specific ion transporters (also referred to as ion pumps).
  • The cell multiplied by duplicating all its contents followed by cellular division.
  • The cell used chemiosmosis to produce energy. It also reduced CO2 and oxidized H2 (methanogenesis or acetogenesis) via acetyl-thioesters [14][15]

Hypotheses[edit]

Current tree of life showing horizontal gene transfers

In 1859, Charles Darwin published The Origin of Species in which he twice stated the hypothesis that there was only one progenitor for all life forms. In the summation he states, "Therefore I should infer from analogy that probably all the organic beings which have ever lived on this earth have descended from some one primordial form, into which life was first breathed."[16] The very last sentence is a restatement of the hypothesis: "There is grandeur in this view of life, with its several powers, having been originally breathed into a few forms or into one."[16]

When LUA was hypothesized, cladograms based on genetic distance between living cells indicated that Archaea split early from the rest of life. This was inferred from the fact that all known archaeans were highly resistant to environmental extremes such as high salinity, temperature or acidity, and led some scientists to suggest that LUA evolved in areas like the deep ocean vents, where such extremes prevail today. Archaea, however, were discovered in less hostile environments and are now believed to be more closely related to eukaryotes than bacteria, although many details are still unknown.[17][18]

In 2010, based on "the vast array of molecular sequences now available from all domains of life,"[19] a formal test of universal common ancestry was published.[2] The formal test favored the existence of a universal common ancestor over a wide class of alternative hypotheses that included horizontal gene transfer. While the formal test overwhelmingly favored the existence of a single LUA, this does not imply that LUA was ever alone. Instead, it was a member of the early microbial community.[2] Given that many other nucleotides are possible besides adenine (A), thymine (T, DNA only), guanine (G), cytosine (C), and uracil (U, RNA only), it is extremely unlikely that organisms descendent from separate abiogenesis events (that is to say separate incidents where organic molecules initially came together to form cell-like structures) would be able to complete a horizontal gene transfer without garbling each other's genes, converting them into noncoding segments. Also, many more amino acids are chemically possible than the twenty found in modern protein molecules. These lines of chemical evidence, taken into account for the formal statistical test by Theobald (2010), point to a single cell's having been LUA in that, although it was a member of the early microbial community, only its descendents survived beyond the Paleoarchean Era.[citation needed] With a common framework in the AT/GC rule and the standard twenty amino acids, horizontal gene transfer would have been feasible and may have been very common later on among the progeny of that single cell.

In 1998, Carl Woese proposed (1) that no individual organism can be considered a LUA, and (2) that the genetic heritage of all modern organisms derived through horizontal gene transfer among an ancient community of organisms.[20] While the results described by the later papers Theobald (2010) and Saey (2010) demonstrate the existence of a single LUCA, the argument in Woese (1998) can still be applied to Ur-organisms. At the beginnings of life, ancestry was not as linear as it is today because the genetic code took time to evolve.[21] Before high fidelity replication, organisms could not be easily mapped on a phylogenetic tree. Not to be confused with the Ur-organism, however, LUCA lived after the genetic code and at least some rudimentary early form of molecular proofreading had already evolved. It was not the very first cell, but rather, the one whose descendents survived beyond the very early stages of microbial evolution.

Location of the root[edit]

For branching of Bacteria phyla, see Bacterial phyla.

The most commonly accepted location of the root of the tree of life is between a monophyletic domain Bacteria and a clade formed by Archaea and Eukaryota of what is referred to as the "traditional tree of life" based on several molecular studies starting with C. Woese.[22] A very small minority of studies have concluded differently, namely that the root is in the Domain Bacteria, either in the phylum Firmicutes[23] or that the phylum Chloroflexi is basal to a clade with Archaea+Eukaryotes and the rest of Bacteria as proposed by Thomas Cavalier-Smith.[24]

See also[edit]

References[edit]

  1. ^ Woese CR, Kandler O, Wheelis ML (June 1990). "Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya". Proceedings of the National Academy of Sciences of the United States of America 87 (12): 4576–9. doi:10.1073/pnas.87.12.4576. PMC 54159. PMID 2112744. 
  2. ^ a b c Theobald DL (May 2010). "A formal test of the theory of universal common ancestry". Nature 465 (7295): 219–22. Bibcode:2010Natur.465..219T. doi:10.1038/nature09014. PMID 20463738. 
  3. ^ Doolittle WF (February 2000). "Uprooting the tree of life". Scientific American 282 (2): 90–5. doi:10.1038/scientificamerican0200-90. PMID 10710791. 
  4. ^ Glansdorff N, Xu Y, Labedan B (2008). "The last universal common ancestor: emergence, constitution and genetic legacy of an elusive forerunner". Biology Direct 3: 29. doi:10.1186/1745-6150-3-29. PMC 2478661. PMID 18613974. 
  5. ^ Ohtomo, Yoko; Kakegawa, Takeshi; Ishida, Akizumi; Nagase, Toshiro; Rosing, Minik T. (2013). "Evidence for biogenic graphite in early Archaean Isua metasedimentary rocks". Nature Geoscience 7: 25–8. Bibcode:2014NatGe...7...25O. doi:10.1038/ngeo2025. 
  6. ^ Borenstein, Seth (13 November 2013). "Oldest fossil found: Meet your microbial mom". AP News. Retrieved 15 November 2013. 
  7. ^ Noffke N, Christian D, Wacey D, Hazen RM (December 2013). "Microbially induced sedimentary structures recording an ancient ecosystem in the ca. 3.48 billion-year-old Dresser Formation, Pilbara, Western Australia". Astrobiology 13 (12): 1103–24. doi:10.1089/ast.2013.1030. PMC 3870916. PMID 24205812. 
  8. ^ Darwin, C. (1859), The Origin of Species by Means of Natural Selection, John Murray, p. 490 
  9. ^ Wächtershäuser, Günter (1998). "Towards a Reconstruction of Ancestral Genomes by Gene Cluster Alignment". Systematic and Applied Microbiology 21 (4): 473–4, IN1, 475–7. doi:10.1016/S0723-2020(98)80058-1. 
  10. ^ Gregory, Michael. "What is Life?". Clinton College. 
  11. ^ Pace NR (January 2001). "The universal nature of biochemistry". Proceedings of the National Academy of Sciences of the United States of America 98 (3): 805–8. Bibcode:2001PNAS...98..805P. doi:10.1073/pnas.98.3.805. PMC 33372. PMID 11158550. 
  12. ^ Wächtershäuser G (January 2003). "From pre-cells to Eukarya--a tale of two lipids". Molecular Microbiology 47 (1): 13–22. doi:10.1046/j.1365-2958.2003.03267.x. PMID 12492850. 
  13. ^ Marshall, Michael. "Life began with a planetary mega-organism". New Scientist. 
  14. ^ Martin W, Russell MJ (October 2007). "On the origin of biochemistry at an alkaline hydrothermal vent". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 362 (1486): 1887–925. doi:10.1098/rstb.2006.1881. PMC 2442388. PMID 17255002. 
  15. ^ Lane N, Allen JF, Martin W (April 2010). "How did LUCA make a living? Chemiosmosis in the origin of life". BioEssays 32 (4): 271–80. doi:10.1002/bies.200900131. PMID 20108228. 
  16. ^ a b Darwin, Charles. On the Origin of Species. London: John Murray, Albermarle Street. 1859. Pg. 484 and 490.
  17. ^ Xie Q, Wang Y, Lin J, Qin Y, Wang Y, Bu W (2012). "Potential key bases of ribosomal RNA to kingdom-specific spectra of antibiotic susceptibility and the possible archaeal origin of eukaryotes". PLoS ONE 7 (1): e29468. doi:10.1371/journal.pone.0029468. PMC 3256160. PMID 22247777. 
  18. ^ Yutin N, Makarova KS, Mekhedov SL, Wolf YI, Koonin EV (August 2008). "The deep archaeal roots of eukaryotes". Molecular Biology and Evolution 25 (8): 1619–30. doi:10.1093/molbev/msn108. PMC 2464739. PMID 18463089. 
  19. ^ Steel M, Penny D (May 2010). "Origins of life: Common ancestry put to the test". Nature 465 (7295): 168–9. Bibcode:2010Natur.465..168S. doi:10.1038/465168a. PMID 20463725. 
  20. ^ Woese C (June 1998). "The universal ancestor". Proceedings of the National Academy of Sciences of the United States of America 95 (12): 6854–9. Bibcode:1998PNAS...95.6854W. doi:10.1073/pnas.95.12.6854. PMC 22660. PMID 9618502. 
  21. ^ Maynard Smith, John; Szathmáry, Eörs (1995). The Major Transitions in Evolution. Oxford, England: Oxford University Press. ISBN 0-19-850294-X. [page needed]
  22. ^ Boone, David R.; Castenholz, Richard W.; Garrity, George M. (eds.). The Archaea and the Deeply Branching and Phototrophic Bacteria. Bergey's Manual of Systematic Bacteriology. ISBN 978-0-387-21609-6. [page needed]
  23. ^ Valas RE, Bourne PE (2011). "The origin of a derived superkingdom: how a gram-positive bacterium crossed the desert to become an archaeon". Biology Direct 6: 16. doi:10.1186/1745-6150-6-16. PMC 3056875. PMID 21356104. 
  24. ^ Cavalier-Smith T (2006). "Rooting the tree of life by transition analyses". Biology Direct 1: 19. doi:10.1186/1745-6150-1-19. PMC 1586193. PMID 16834776.