Latonia Moore was born in Houston, Texas. She grew up with black music, and at the age of eight, began to sing in the church choir of the New Sunrise Baptist Church, where her grandfather Cranford Moore was a pastor.
She studied first gospel and jazz, until one of her teachers at the University of North Texas convinced her to study classical music. This required a major technical change, since for both gospel and jazz, the chest voice is used more in higher pitches, while the high, pure tones of opera singing require mainly head voice. She continued as a student of Bill Schuman at the Academy of Vocal Arts, Philadelphia, where she graduated in 2005.
Moore made her debut in 1998 at the Palm Beach Opera in West Palm Beach, and was engaged as a student in the same year at the Houston Ebony Opera. Her repertoire includes Donna Anna in Don Giovanni, Lucrezia in Lucrezia Borgia, Violetta in La Traviata, Marguerite in Faust, and Tatiana in Eugene Onegin. In the role of Mimi in La Bohème, she appeared at the Dresden Semper Opera, as Micaela in Carmen in Dallas and New York City Opera. As Liù in Turandot, she debuted at London's Royal Opera House in Covent Garden. She has sung the title role in Aïda at the Hamburg State Opera, Covent Garden, and the Metropolitan Opera.
Moore also performs in concert. She is among other things on the German Grammophon recording of Mahler's 2nd Symphony, a 2002 recording from the Vienna Musikverein, conducted by the American multi-millionaire and Mahler enthusiast Gilbert Kaplan.
Her Metropolitan Opera debut, replacing Violeta Urmana at short notice as Aïda in a live broadcast, was greeted by tumultuous audience acclaim.
- Mimì in La Bohème at Semperoper, Dresden, Germany
- Liù in Turandot at Royal Opera House/Covent Garden,
- Aïda in Verdi's Aïda, in the 2009/2010 season at the Hamburgsche Staatsoper, and in 2011 at Covent Garden.
- March 2012 debut at the Metropolitan Opera  in the title role of Aïda.
- 2005 Richard Tucker Foundation Grant
- 2003 first prize and audience award at Concours International d'Opéra in Marseille
- 2003 special prize "Kammeroper der Internationalen Hans Gabor Belvedere Gesangswettbewerbe"
- 2002 first prize for soprano at the Licia Albanese Puccini Competition
- 2002 first prize and audience award "Internationalen Gesangswettbewerbs der italienischen Oper Dresden", Germany
- 2000 Metropolitan Opera’s National Council Auditions 
- Hugh Canning - Opera - 3/2009 Volume 60.
- Rosaly M. Story: If I Could Sing Like a Daughter of God. In: Opera News. Band 74, Nr. 12 (Juni 2010), ISSN 0030-3607.
- Metropolitan Opera Debut (viewed 02.03.2012)
- Hamburgische Staatsoper Sopran Latonia Moore (last visited 02.03.2012)
-  www.liciaalbanesepuccinifnd.org
- Athony Tommasini: Listening to the Future At the Met Auditions. In: New York Times vom 8. März 2000.
- Grammophone online