Laurel High School was founded in 1899 with an enrollment of 59 students and four teachers. According to The Washington Post, the 1900 graduating class was all women. The original school building was listed on the National Register of Historic Places in 1979. In 1965, the school moved to a larger building at 8000 Cherry Lane in Laurel, and annexed an adjacent elementary school in 1983. Laurel shares the same layout as Bowie High School, in neighboring Bowie, Maryland. Today, Laurel High School enrolls roughly 1,990 students in grades 9 through 12. The school mascot is the Spartan, and the school colors are blue and gold.
Fulfilling an objective of the Prince George’s County Capital Improvement Program since 1989, construction on a new 800-seat auditorium for the school was expected to begin in February 2009. The addition was completed in the early 2010 school year.
Laurel High's student newspaper, "The Shield", established in the 1995–1996 school year, has won awards from the American Scholastic Press Association and the Columbia Scholastic Press Association. Prior to the 1995–96 school year, the school paper operated under the name "The Tattler".