Loxtidine

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Loxtidine
Loxtidine structure.png
Systematic (IUPAC) name
[1-methyl-5-({3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}amino)-1H-1,2,4-triazol-3-yl]methanol
Clinical data
Legal status
  • Uncontrolled
Routes Oral
Identifiers
CAS number 76956-02-0
ATC code None
PubChem CID 55473
ChemSpider 50093
UNII X16K5179V5
Chemical data
Formula C19H29N5O2 
Mol. mass 359.47 g/mol

Lavoltidine (INN, USAN, BAN; code name AH-23,844), previously known as loxtidine, is a highly potent and selective H2 receptor antagonist which was under development as a treatment for gastroesophageal reflux disease but was discontinued due to the discovery that it produced gastric carcinoid tumors in rodents.[1][2]

See also[edit]

References[edit]

  1. ^ Washington, Neena (1991). Antacids and anti-reflux agents. Boca Raton: CRC Press. ISBN 0-8493-5444-7. 
  2. ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.