He was appointed definitor general to Rome for the Capuchins in 1596; Pope Clement VIII assigned him the task of converting the Jews in the city. Beginning in 1599, Lawrence established Capuchin monasteries in modern Germany and Austria, furthering the Counter-Reformation and bringing many Protestants back to the Catholic faith.
In 1602, he was elected vicar general of the Capuchin friars, at that time the highest office in the Order. He was elected again in 1605, but refused the office. He entered the service of the Holy See, becoming papal nuncio to Bavaria. After serving as nuncio to Spain, he retired to a monastery in 1618. He was recalled as a special envoy to the King of Spain regarding the actions of the Viceroy of Naples in 1619, and after finishing his mission, died on his birthday in Lisbon.