Lecithin—cholesterol acyltransferase

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Lecithin-cholesterol acyltransferase
Identifiers
Symbol LCAT
External IDs OMIM606967 MGI96755 HomoloGene68042 ChEMBL: 5942 GeneCards: LCAT Gene
EC number 2.3.1.43
Orthologs
Species Human Mouse
Entrez 3931 16816
Ensembl ENSG00000213398 ENSMUSG00000035237
UniProt P04180 P16301
RefSeq (mRNA) NM_000229 NM_008490
RefSeq (protein) NP_000220 NP_032516
Location (UCSC) Chr 16:
67.97 – 67.98 Mb
Chr 8:
105.94 – 105.94 Mb
PubMed search [1] [2]

Lecithin—cholesterol acyltransferase (LCAT, also called phosphatidylcholine-sterol O-acyltransferase) is an enzyme that converts free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface. The enzyme is bound to high-density lipoproteins (HDLs) and low-density lipoproteins in the blood plasma.

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Statin_Pathway_WP430 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article
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  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". 

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