Lecithin retinol acyltransferase

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Lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
Identifiers
Symbols LRAT ; LCA14
External IDs OMIM604863 MGI1891259 HomoloGene3483 ChEMBL: 2202 GeneCards: LRAT Gene
EC number 2.3.1.135
RNA expression pattern
PBB GE LRAT 220317 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9227 79235
Ensembl ENSG00000121207 ENSMUSG00000028003
UniProt O95237 Q9JI60
RefSeq (mRNA) NM_004744 NM_023624
RefSeq (protein) NP_004735 NP_076113
Location (UCSC) Chr 4:
155.55 – 155.67 Mb
Chr 3:
82.89 – 82.9 Mb
PubMed search [1] [2]

Lecithin retinol acyltransferase is an enzyme that in humans is encoded by the LRAT gene.[1][2]

Function[edit]

Lecithin retinol acyltransferase is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester during phototransduction, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver.

Clinical significance[edit]

Mutations in this gene have been associated with early-onset severe retinal dystrophy.[2]

LRAT was overexpressed in colorectal cancer cells compared to normal colonic epithelium. Strong LRAT expression was associated with a poor prognosis in patients with colorectal cancer.[3]

See also[edit]

References[edit]

  1. ^ Ruiz A, Winston A, Lim YH, Gilbert BA, Rando RR, Bok D (Feb 1999). "Molecular and biochemical characterization of lecithin retinol acyltransferase". J Biol Chem 274 (6): 3834–41. doi:10.1074/jbc.274.6.3834. PMID 9920938. 
  2. ^ a b "Entrez Gene: LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)". 
  3. ^ Brown, Gordon; Beatriz Cash; Daniela Blihoghe; Petronella Johansson; Ayham Alnabulsi; Graeme Murray (2014-03-07). "The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer". PLOS ONE. doi:10.1371/journal.pone.0090776. 

Further reading[edit]

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