Lecozotan

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Lecozotan
Lecozotan structure.svg
Systematic (IUPAC) name
4-Cyano-N-[(2R)-2-[4-(2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl]propyl]-N-2-pyridinylbenzamide hydrochloride
Clinical data
Legal status ?
Identifiers
CAS number 434283-16-6
ATC code None
PubChem CID 11156648
UNII 48854OTZ5E YesY
KEGG D04683 YesY
Chemical data
Formula C28H30ClN5O3 
Mol. mass 520.021 g/mol
 YesY (what is this?)  (verify)

Lecozotan is an investigational drug by Wyeth tested for improvement of cognitive functions of Alzheimer's disease patients.[1] As of June 2008, the first Phase III clinical trial has been completed.[2]

Method of action[edit]

Lecozotan is a competitive, selective 5-HT1A receptor antagonist[3] which enhances the potassium-stimulated release of acetylcholine and glutamate.[4]

References[edit]

  1. ^ H. Spreitzer (August 13, 2008). "Neue Wirkstoffe - Lecozotan". Österreichische Apothekerzeitung (in German) (17/2007): 805. 
  2. ^ ClinicalTrials
  3. ^ Schlechter, LE; Smith, DL; Rosenzweig-Lipson, S; Sukoff, SJ; Dawson, LA; Marquis, K; Jones, D; Piesla, M et al. (June 10, 2005). "Lecotozan (SRA-333): A selective serotonin1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and promotes procognitive effects". Journal of Pharmacology and Experimental Therapeutics 314 (3): 1274–89. doi:10.1124/jpet.105.086363. PMID 15951399. 
  4. ^ Childers, WE Jr, Harrison, BL, Abou-Gharbia, MA, Raje, S, Parks, V, Pangalos, MN, Schechter, LE (2007). "Lecozotan Hydrochloride". Drugs of the Future 32 (5): 399–407. doi:10.1358/dof.2007.032.05.1092901.