- For singer-songwriter in South Korea, see Lee Tzsche
Lee Sang-Eun (born March 5, 1975) is a female South Korean handball player who competed in the 1996 Summer Olympics, in the 2000 Summer Olympics, and in the 2004 Summer Olympics.
In 1996 she was part of the South Korean team which won the silver medal. She played five matches and scored 14 goals.
Four years later she was part of the South Korean team which finished fourth in the 2000 Olympic tournament. She played all seven matches and scored 59 goals.
In 2004 she won the silver medal with the South Korean team again. She played all seven matches and scored 44 goals.