Leishmania braziliensis

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Leishmania braziliensis
Scientific classification
Domain: Eukaryota
(unranked): Excavata
Phylum: Euglenozoa
Binomial name
Leishmania braziliensis

Leishmania brasiliensis is a Leishmania species.[1]

It is associated with leishmaniasis.

Signs and symptoms[edit]

Within a few months of infection, an ulcer forms. After healing there is an asymptomatic phase for three to twenty years. At this time, the parasite causes oral and nasal lesions causing severe damage to the mucus membranes.

Treatment[edit]

Pentostam, Liposomal and lipid complex preparations of Amphotericin B, or paromomycin can be given.

Sexual reproduction[edit]

In L. braziliensis, matings in nature are predominantly between related individuals resulting in extreme inbreeding. [2]

References[edit]

  1. ^ Vargas-Inchaustegui DA, Xin L, Soong L (June 2008). "Leishmania braziliensis infection induces dendritic cell activation, ISG15 transcription, and the generation of protective immune responses". J. Immunol. 180 (11): 7537–45. doi:10.4049/jimmunol.180.11.7537. PMC 2641013. PMID 18490754. 
  2. ^ Rougeron V, De Meeûs T, Hide M, Waleckx E, Bermudez H, Arevalo J, Llanos-Cuentas A, Dujardin JC, De Doncker S, Le Ray D, Ayala FJ, Bañuls AL (June 2009). "Extreme inbreeding in Leishmania braziliensis". Proc. Natl. Acad. Sci. U.S.A. 106 (25): 10224–9. doi:10.1073/pnas.0904420106. PMC 2700931. PMID 19497885. 



Further Reading[edit]

Alcazar, Wilmer; Silva-Lopez, Adrian; Alakurtti, Sami; Tuononen, Maija-Liisa; Yli-Kauhaluoma, Jari; Ponte-Sucre, Alicia (1 November 2014). "Betulin derivatives impair Leishmania braziliensis viability and host-parasite interaction". Bioorganic & Medicinal Chemistry 22 (21): 6220–6226. doi:10.1016/j.bmc.2014.08.023. PMID 25240731.