In 1977 Sachs was awarded the Rothschild Prize in the Biological Sciences;
In 1980, he was awarded the Wolf Prize in Medicine, becaming the first Israeli scientist to win the Wolf Prize; for his "contributions to knowledge of the function and dysfunction of the body cells through [his] studies on ... the elucidation of mechanisms governing the control and differentiation of normal and cancer cells".
In 1983 Sachs was awarded the Bristol-Myers Award for Distinguished Achievement in Cancer Research, New York;
In 1985 He was elected Doctor Honoris Causa, Bordeaux University, France;
In 1986 Sachs was awarded The Royal Society Wellcome Foundation Prize, London;
In 1989 Sachs was awarded Alfred P. Sloan Prize, General Motors Cancer Research Foundation, New York;
In 1996, Sachs received the Ot Hanagid (Medal of the Governor) award, presented annually by Jerusalem's Shaare Zedek Medical Center, for his pioneering work in cancer research. The presentation noted that "He discovered and identified a group of proteins among them colony-stimulating factors and some interleukins that control the viability and growth of blood stem cells and their development into different types of mature blood cells." It noted further that his "research in the 1950s on the use of amniotic fluid to diagnose a fetus s genetic properties has formed the basis for today's prenatal diagnosis of human diseases."