Lepirudin
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| Systematic (IUPAC) name | |
| [Leu1,Thr2]-63-desulfohirudin | |
| Clinical data | |
| Trade names | Refludan |
| AHFS/Drugs.com | monograph |
| Pregnancy cat. | B(US) |
| Legal status | ? |
| Routes | SQ or IV |
| Pharmacokinetic data | |
| Bioavailability | 100% |
| Half-life | ~1.3 hours |
| Excretion | Renal |
| Identifiers | |
| CAS number | 120993-53-5  |
| ATC code | B01AE02 |
| DrugBank | BTD00024 |
| UNII | Y43GF64R34  |
| KEGG | D03692 |
| ChEMBL | CHEMBL1201666 |
| Chemical data | |
| Formula | C288H448N80O110S6 |
| Mol. mass | 6983.5 g/mol |
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Lepirudin is an anticoagulant that functions as a direct thrombin inhibitor.
Brand name: Refludan, Generic: Lepirudin rDNA for injection.
Lepirudin is a recombinant hirudin[1] derived from yeast cells. It is almost identical to hirudin extracted from Hirudo medicinalis. It differs by the substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63.
Lepirudin may be used as an anticoagulant when heparins (unfractionated or low-molecular-weight) are contra-indicated because of heparin-induced thrombocytopenia.
[edit] References
- ^ Arman T. Askari; A. Michael Lincoff (October 2009). Antithrombotic Drug Therapy in Cardiovascular Disease. Springer. pp. 440–. ISBN 9781603272346. http://books.google.com/books?id=iadLoXoQkWEC&pg=PA440. Retrieved 30 October 2010.
[edit] External links
- DDB 30082
- Smythe M, Stephens J, Koerber J, Mattson J (2005). "A comparison of lepirudin and argatroban outcomes.". Clin Appl Thromb Hemost 11 (4): 371–4. doi:10.1177/107602960501100403. PMID 16244762.
- Tardy, B; Lecompte, T; Boelhen, F; Tardy-Poncet, B; Elalamy, I; Morange, P; Gruel, Y; Wolf, M et al. (2006). "Predictive factors for thrombosis and major bleeding in an observational study in 181 patients with heparin-induced thrombocytopenia treated with lepirudin.". Blood 108 (5): 1492–6. doi:10.1182/blood-2006-02-001057. PMID 16690967.
- Lubenow N, Eichler P, Lietz T, Greinacher A (2005). "Lepirudin in patients with heparin-induced thrombocytopenia - results of the third prospective study (HAT-3) and a combined analysis of HAT-1, HAT-2, and HAT-3.". J Thromb Haemost 3 (11): 2428–36. doi:10.1111/j.1538-7836.2005.01623.x. PMID 16241940.
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