Lercanidipine

Lercanidipine

Systematic (IUPAC) name
2[(3,3-diphenylpropyl)(methyl)amino]-1,1-dimethylethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	100427-26-7
ATC code	C08CA13
PubChem	CID 65866
DrugBank	APRD00193
ChemSpider	59276 Y
UNII	V7XTJ4R0BH Y
KEGG	D08111 Y
ChEMBL	CHEMBL250270 Y
Chemical data
Formula	C36H41N3O6
Mol. mass	611.727 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C36H41N3O6/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27/h7-19,22,30,33,37H,20-21,23H2,1-6H3 Y Key:ZDXUKAKRHYTAKV-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Lercanidipine is a calcium channel blocker of the dihydropyridine class.It is sold under various commercial names including Zanidip,which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. This lowers the blood pressure and allows the heart to work more efficiently.

Further reading

• Lin T, Voon W, Yen H, Huang C, Su H, Lai W, Sheu S (2006). "Lercanidipine and losartan effects on blood pressure and fibrinolytic parameters.". Kaohsiung J Med Sci 22 (4): 177–83. doi:10.1016/S1607-551X(09)70304-3. PMID 16679299. 
• Martinez M, Lopes L, Coelho E, Nobre F, Rocha J, Gerlach R, Tanus-Santos J (2006). "Lercanidipine reduces matrix metalloproteinase-9 activity in patients with hypertension.". J Cardiovasc Pharmacol 47 (1): 117–22. doi:10.1097/01.fjc.0000196241.96759.71. PMID 16424795. 
• Agrawal R, Marx A, Haller H (2006). "Efficacy and safety of lercanidipine versus hydrochlorothiazide as add-on to enalapril in diabetic populations with uncontrolled hypertension.". J Hypertens 24 (1): 185–92. doi:10.1097/01.hjh.0000198987.34588.11. PMID 16331117. 

External links

• DDB 31597