The music video was shot on location at Slauson Avenue in Los Angeles and was directed by Dr. Dre. It is the second lowrider cult video of Dre's cinematographer "walk of life" that was nominated for a MTV Video Music Award for Best Rap Video in the same year. The video begins with Dre, in his home watching the $20 Dollar Sack Pyramid (a track skit from the album shown as a game show in the video), taking a phone call and being invited to a Parliament concert. He then heads out in his lowrider and the song begins. Many helicopter-view camshots of the super-highways of Compton follow, some cuts of Snoop, a car-jacking scene, and various footage of Dre picking up girls, all of which leads to a street party outside the concert venue. Ice Cube makes a cameo appearance, walking out from a women's bathroom saying "Damn right, it was a good day", referring to his 1992 solo single, and also officially squashing the beef between Dre and Ice Cube which had existed since Ice Cube left N.W.A.
The final shots of the video feature footage from Parliament and Funkadelic's 1976 earth tour, including the Starchild flying on wires with the bop gun, the band singing "Mothership Connection", which "Let Me Ride" samples, and concludes with George Clinton departing into the Mothership with a plume of smoke, upon which Dre's face is superimposed.
An official remix of the song features full verses from Snoop Dogg and Daz, and an appearance by George Clinton. It was recorded simultaneously with the original version and was released on the 12" vinyl when the solo version was chosen to be a part of the album. The full version of the remix is 11 minutes long and features a guitar solo by Johnny "Guitar" Watson. The beat was later remade as a G-Funk remix and the instrumental was used for the Up In Smoke Tour in 2000. Dr. Dre also produced the beat for the remix.
Nate Dogg refers to "Let Me Ride" in Warren G's 1994 song "Regulate", in which he sings, "She said 'my car's broke down and you seem real nice, would ya let me ride?'"
Rapper Fabolous, in his 2001 hit "Can't Deny It", had the lyric "bitches be yellin "let me ride", like I'm Snoop, and Dr. Dre.". Rapper The Game similarly refers to "Let Me Ride" in his 2005 song "Put You on the Game", where he claims to be in a car with Dre in the back and "bitches screaming, 'Let me ride!'".