Leukocyte immunoglobulin-like receptors

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The leukocyte immunoglobulin-like receptors (LILR) are a family of receptors possessing extracellular immunoglobulin domains.[1] They are also known as CD85, ILTs and LIR, and can exert immunomodulatory effects on a wide range of immune cells.[2] The human genes encoding these receptors are found in a gene cluster at chromosomal region 19q13.4.

They include

A subset of LILR recognise MHC class I (also known as HLA class I in humans). Of these, the inhibitory receptors LILRB1 and LILRB2 show a broad specificity for classical and non-classical MHC alleles with preferential binding to b2m-associated complexes. In contrast, the activating receptors LILRA1 and LILRA3 prefer b2m-independent free heavy chains of MHC class I, and in particular HLA-C alleles.[3]

See also[edit]

References[edit]

  1. ^ David E. Sloane, Nicodemus Tedla, Muyiwa Awoniyi, Donald W. MacGlashan Jr., Luis Borges, K. Frank Austen & Jonathan P. Arm (November 2004). "Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition" (PDF). Blood 104 (9): 2832–2839. doi:10.1182/blood-2004-01-0268. PMID 15242876. 
  2. ^ Damian Brown, Rachel L Allen, & John Trowsdale. The LILR family: modulators of innate and adaptive immune pathways in health and disease. Tissue Antigens (2004) 64:215 http://onlinelibrary.wiley.com/doi/10.1111/j.0001-2815.2004.00290.x/pdf
  3. ^ Jones DC, Kosmoliaptsis V, Apps R, Lapaque N, Smith I, Kono A, Chang C, Boyle LH, Taylor CJ, Trowsdale J, Allen RL (Mar 2011). "HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding". J Immunol 186 (5): 2990–7. doi:10.4049/jimmunol.1003078. PMID 21270408.