Leukotriene B4

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Leukotriene B4
Leukotriene B4.svg
Names
IUPAC name
(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-icosatetraenoic acid
Identifiers
71160-24-2 YesY
ChEBI CHEBI:15647 N
ChEMBL ChEMBL65061 N
ChemSpider 4444132 N
Jmol-3D images Image
KEGG C02165 N
PubChem 5280492
Properties
C20H32O4
Molar mass 336.466
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

Leukotriene B4 is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on the endothelium, allowing them to bind to and cross it into the tissue.[1] In neutrophils, it is also a potent chemoattractant, and is able to induce the formation of reactive oxygen species and the release of lysosome enzymes by these cells.[1] It is synthesized by leukotriene-A4 hydrolase from leukotriene A4.[2]

Eicosanoid synthesis. (Leukotrienes at right.)

References[edit]

  1. ^ a b Cotran; Kumar, Collins. Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X. 
  2. ^ http://www.uniprot.org/uniprot/P09960. Retrieved 9 April 2013.  Missing or empty |title= (help)