Leukotriene C4 synthase

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Leukotriene C4 synthase
Protein LTC4S PDB 2PNO.png
Rendering based on PDB 2PNO.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols LTC4S ; MGC33147
External IDs OMIM246530 MGI107498 HomoloGene7406 ChEMBL: 1743183 GeneCards: LTC4S Gene
EC number 4.4.1.20
Orthologs
Species Human Mouse
Entrez 4056 17001
Ensembl ENSG00000213316 ENSMUSG00000020377
UniProt Q16873 Q60860
RefSeq (mRNA) NM_145867 NM_008521
RefSeq (protein) NP_665874 NP_032547
Location (UCSC) Chr 5:
179.22 – 179.22 Mb
Chr 11:
50.24 – 50.24 Mb
PubMed search [1] [2]

Leukotriene C4 synthase is an enzyme that in humans is encoded by the LTC4S gene.[1][2]

The protein encoded by this gene, LTC4S (or glutathione S-transferase II) is an enzyme that converts leukotriene A4 and glutathione to create leukotriene C4. This is a member of MAPEG family of transmembrane proteins. A trimer of Leukotriene C4 synthase is localized on the outer nuclear membrane and endoplasmic reticulum, where it forms a complex with 5-Lipoxygenase-activating protein. This protein is remotely related to microsomal glutathione S-transferase.

Function[edit]

The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum.[2]

Eicosanoid synthesis. (Leukotrienes at right.)

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