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Leukotriene D4 (LTD-4) is one of the leukotrienes. Its function main in the body is to induce the contraction of smooth muscle, resulting in bronchoconstriction and vasoconstriction. It also increases vascular permeability. LTD-4 is released by basophils. Other leukotrienes that function in a similar manner are leukotrienes C4 and E4. Pharmacological agents that inhibit the function of these leukotrienes are leukotriene receptor antagonists (e.g. Zafirlukast, montelukast) and are useful for asthmatic individuals.
Eicosanoid synthesis. (Leukotrienes at right.)