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Lexitropsins are members of a family of semi-synthetic DNA-binding ligands.[1] They are analogs of the natural antibiotics netropsin and distamycin. Antibiotics of this group are capable to bind in the minor groove of DNA with different sequence-selectivity.[2][3] Lexitropsins form a complexes with DNA with stoichiometry 1:1 and 2:1. Based on the 2:1 complexes were obtained ligands with high sequence-selectivity. [4]

Two groups of lexitropsins

See also[edit]


  1. ^ Sondhi S.M., Praveen Reddy B.S. and Lown J.W. (1997). "Lexitropsin conjugates : Action on DNA targets". Current medicinal chemistry 4: 313–358. 
  2. ^ Goodsell D.S., Ng H.L., Kopka M.L., Lown J.W., Dickerson R.E. (1995). "Structure of a dicationic monoimidazole lexitropsin bound to DNA". Biochemistry 34 (51): 16654–61. doi:10.1021/bi00051a013. PMID 8527438. 
  3. ^ Goodsell D.S. (2001). "Sequence recognition of DNA by lexitropsins". Curr Med Chem 8 (5): 509–16. doi:10.2174/0929867003373319. PMID 11281838. 
  4. ^ M.L. Kopka, D.S. Goodsell, G. Won Han, Th.K. Chiu, J.W. Lown and R.E. Dickerson (1997). "Defining GC-specificity in the minor groove: side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G". Structure 5: 1033–1046. doi:10.1016/s0969-2126(97)00255-4.