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Systematic (IUPAC) name
Clinical data
Legal status
  • Development terminated
Routes Oral
CAS number 1198790-53-2
ATC code None
PubChem CID 58212050
ChemSpider 29271896
Chemical data
Formula C24H22N4 
Molecular mass 366.458 g/mol

Liafensine (BMS-820836) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) which was under development by Bristol-Myers Squibb for the treatment of major depressive disorder.[1] Though it demonstrated comparable effectiveness to escitalopram and duloxetine in phase II clinical trials, development was terminated in 2013 because liafensine failed to show superior effectiveness relative to these drugs, a decision which was made likely based on its increased capacity for side effects as well as its potential for abuse.[1]

See also[edit]


  1. ^ a b "Digest". Progress in Neurology and Psychiatry 17 (5): 41–43. 2013. doi:10.1002/pnp.305. ISSN 1367-7543.