Life extension science, also known as anti-aging medicine, indefinite life extension, experimental gerontology, and biomedical gerontology, is the study of slowing down or reversing the processes of aging to extend both the maximum and average lifespan. Some researchers in this area, and "life extensionists", "immortalists" or "longevists" (those who wish to achieve longer lives themselves), believe that future breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, pharmaceuticals, and organ replacement (such as with artificial organs or xenotransplantations) will eventually enable humans to have indefinite lifespans (agerasia) through complete rejuvenation to a healthy youthful condition.
The sale of putative anti-aging products such as nutrition, physical fitness, skin care, hormone replacements, vitamins, supplements and herbs is a lucrative global industry, with the US market generating about $50 billion of revenue each year. Some medical experts state that the use of such products has not been proven to affect the aging process and many claims regarding the efficacy of these marketed products have been roundly criticized by medical experts, including the American Medical Association.
However, it has not been shown that the goal of indefinite human lifespans itself is necessarily unfeasible; some animals such as hydra, planarian flatworms, and certain sponges, corals, and jellyfish do not die of old age and exhibit potential immortality. The ethical ramifications of life extension are debated by bioethicists.
- 1 Public opinion
- 2 Average and maximum lifespans
- 3 Current anti-aging strategies and issues
- 3.1 Diets and supplements
- 3.2 Hormone treatments
- 3.3 Scientific controversy regarding anti-aging nutritional supplementation and medicine
- 3.4 Ethics and politics of anti-aging nutritional supplementation and medicine
- 3.5 Consumer motivations for using anti-aging products
- 4 Proposed strategies of life extension
- 5 History of the life extension movement
- 6 Ethics and politics of life extension
- 7 Aging as a disease
- 8 See also
- 9 Further reading
- 10 References
- 11 External links
Life extension is a controversial topic due to fear of overpopulation and possible effects on society. Religious people are no more likely to oppose life extension than the unaffiliated, though some variation exists between religious denominations. Blacks and Hispanics are more likely to support life extension than white people. Biogerontologist Aubrey De Grey counters the overpopulation critique by pointing out that the therapy could postpone or eliminate menopause, allowing women to space out their pregnancies over more years and thus decreasing the yearly population growth rate. Moreover, the philosopher and futurist Max More argues that, given the fact the worldwide population growth rate is slowing down and is projected to eventually stabilize and begin falling, superlongevity would be unlikely to contribute to overpopulation.
A Spring 2013 Pew Research poll in the United States found that 38% of Americans would want life extension treatments, and 56% would reject it. However, it also found that 68% believed most people would want it and that only 4% consider an "ideal lifespan" to be more than 120 years. The median "ideal lifespan" was 91 years of age and the majority of the public (63%) viewed medical advances aimed at prolonging life as generally good. 41% of Americans believed that radical life extension would be good for society, while 51% said they believed it would be bad for society. One possibility for why 56% of Americans claim they would reject life extension treatments may be due to the cultural perception that living longer would result in a longer period of decrepitude, and that the elderly in our current society are unhealthy.
Average and maximum lifespans
During the process of aging, an organism accumulates damage to its macromolecules, cells, tissues and organs. Specifically, aging is characterized as and thought to be caused by "genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication." Oxidation damage to cellular contents caused by free radicals is believed to contribute to aging as well.
The longest a human has ever been proven to live is 122 years, the case of Jeanne Calment who was born in 1875 and died in 1997, whereas the maximum lifespan of a wildtype mouse, commonly used as a model in research on aging, is about three years. Genetic differences between humans and mice that may account for these different aging rates include differences in efficiency of DNA repair, antioxidant defenses, energy metabolism, proteostasis maintenance, and recycling mechanisms such as autophagy.
Average lifespan in a population is lowered by infant and child mortality, which are frequently linked to infectious diseases or nutrition problems. Later in life, vulnerability to accidents and age-related chronic disease such as cancer or cardiovascular disease play an increasing role in mortality. Extension of expected lifespan can often be achieved by access to improved medical care, vaccinations, good diet, exercise and avoidance of hazards such as smoking.
Maximum lifespan is determined by the rate of aging for a species inherent in its genes and by environmental factors. Widely recognized methods of extending maximum lifespan in model organisms such as nematodes, fruit flies, and mice include caloric restriction, gene manipulation, and administration of pharmaceuticals. Another technique uses evolutionary pressures such as breeding from only older members or altering levels of extrinsic mortality.
Theoretically, extension of maximum lifespan in humans could be achieved by reducing the rate of aging damage by periodic replacement of damaged tissues, molecular repair or rejuvenation of deteriorated cells and tissues, reversal of harmful epigenetic changes, or the enhancement of telomerase enzyme activity. Research geared towards life extension strategies in various organisms is currently under way at a number of academic and private institutions.
Current anti-aging strategies and issues
Diets and supplements
Much life extension research focuses on nutrition—diets or supplements—as a means to extend lifespan, although few of these have been systematically tested for significant longevity effects. The many diets promoted by anti-aging advocates are often contradictory.[original research?] A dietary pattern with some support from scientific research is caloric restriction.
Preliminary studies of caloric restriction on humans using surrogate measurements have provided evidence that caloric restriction may have powerful protective effect against secondary aging in humans. Caloric restriction in humans may reduce the risk of developing Type 2 diabetes and atherosclerosis. More research is needed.
The free-radical theory of aging suggests that antioxidant supplements, such as Vitamin C, Vitamin E, Q10, lipoic acid, carnosine, and N-acetylcysteine, might extend human life. However, combined evidence from several clinical trials suggest that β-Carotene supplements and high doses of Vitamin E increase mortality rates. Other substances proposed to extend lifespan include oxytocin, insulin, human chorionic gonadotropin (hCG), and erythropoietin (EPO). Resveratrol is a sirtuin stimulant that appears to extend lifespan in simple organisms such as nematodes and short-lived fish.
Some supplements, including the minerals selenium or zinc have been reported to extend the lifespan of rats and mice, though none have been proven to do so in humans, and significant toxic effects were observed. Metformin may also extend life span in mice.
There are many traditional herbs purportedly used to extend the health-span, including a Chinese tea called Jiaogulan (Gynostemma pentaphyllum), dubbed "China's Immortality Herb." Ayurveda, the traditional Indian system of medicine, describes a class of longevity herbs called rasayanas, including Bacopa monnieri, Ocimum sanctum, Curcuma longa, Centella asiatica, Phyllanthus emblica, Withania somnifera and many others. Along with their Chinese counterparts (called superior or tonic herbs), Indian rasayanas demonstrate preliminary positive results in animal models.
The anti-aging industry offers several hormone therapies. Some of these have been criticized for possible dangers to the patient and a lack of proven effect. For example, the American Medical Association has been critical of some anti-aging hormone therapies.
Although some recent clinical studies have shown that low-dose growth hormone (GH) treatment for adults with GH deficiency changes the body composition by increasing muscle mass, decreasing fat mass, increasing bone density and muscle strength, improves cardiovascular parameters (i.e. decrease of LDL cholesterol), and affects the quality of life without significant side effects, the evidence for use of growth hormone as an anti-aging therapy is mixed and based on animal studies. An early study suggested that supplementation of mice with growth hormone increased average life expectancy. Additional animal experiments have suggested that growth hormone may generally act to shorten maximum lifespan; knockout mice lacking the receptor for growth hormone live especially long. Furthermore, mouse models lacking the insulin-like growth factor also live especially long and have low levels of growth hormone.
Insulin like growth factor (IGF-1) restriction
People suffering from a rare condition known as Laron syndrome have a mutation in the gene that makes the receptor for growth hormone. It is theorised that this mutation may hold a key to life extension.
Longo said that some level of IGF-1 was necessary to protect against heart disease, but that lowering the level might be beneficial. A drug that does this is already on the market for treatment of acromegaly, a thickening of the bones caused by excessive growth hormone. “Our underlying hypothesis is that this drug would prolong life span,” Longo said. He said he was not taking the drug, called pegvisomant or Somavert, which is very hard to obtain.
Scientific controversy regarding anti-aging nutritional supplementation and medicine
Some critics dispute the portrayal of aging as a disease. For example, Leonard Hayflick, who determined that fibroblasts are limited to around 50 cell divisions, reasons that aging is an unavoidable consequence of entropy. Hayflick and fellow biogerontologists Jay Olshansky and Bruce Carnes have strongly criticized the anti-aging industry in response to what they see as unscrupulous profiteering from the sale of unproven anti-aging supplements.
Ethics and politics of anti-aging nutritional supplementation and medicine
Politics relevant to the substances of life extension pertain mostly to communications and availability.
In the United States, product claims on food and drug labels are strictly regulated. The First Amendment (freedom of speech) protects third-party publishers' rights to distribute fact, opinion and speculation on life extension practices. Manufacturers and suppliers also provide informational publications, but because they market the substances, they are subject to monitoring and enforcement by the Federal Trade Commission (FTC), which polices claims by marketers. What constitutes the difference between truthful and false claims is hotly debated and is a central controversy in this arena.
Consumer motivations for using anti-aging products
Research by Sobh and Martin (2011) suggests that people buy anti-aging products to obtain a hoped-for self (e.g., keeping a youthful skin) or to avoid a feared-self (e.g., looking old). The research shows that when consumers pursue a hoped-for self, it is expectations of success that most strongly drive their motivation to use the product. The research also shows why doing badly when trying to avoid a feared self is more motivating than doing well. Interestingly, when product use is seen to fail it is more motivating than success when consumers seek to avoid a feared-self.
Proposed strategies of life extension
There are a number of drugs intended to slow the aging process currently being researched. One type of research is related to the observed effects a calorie restriction diet, which has been shown to extend lifespan in some animals Based on that research, there have been attempts to develop drugs that will have the same effect on the aging process as a caloric restriction diet, which are known as Caloric restriction mimetic drugs. Drugs that have been studied for possible longevity effects on laboratory animals because of a possible CR-mimic effect include Rapamycin, Metformin, and Resveratrol. Two drugs that may have potential benefits of combating age-related maladies are Resveratrol and Rapamycin. These drugs are considered to be the forefront drugs in anti-aging research. Before these drugs had been tested, the best-characterized anti-aging therapy was, and still is, calorie restriction or CR. In some studies calorie restriction has been shown to extend the life of mice, yeast, and rhesus monkeys significantly. However, a more recent study has shown that in contrast, calorie restriction has not improved the survival rate in rhesus monkeys. Long-term human trials of CR are now being done.It is the hope of the anti-aging researchers that Resveratrol and Rapamycin may act as CR mimetics to increase the life span of humans.
Resveratrol was first thought to be an activator of sirtuins, a family of deacetylases, that would promote anti aging effects without having to restrict caloric intake. However, recent replication studies have failed to show that Resveratrol increases the life span in yeast or mice and that Resveratrol may not activate sirtuins that are biologically beneficial to age reduction. Another study was done showing that Resveratrol activates or inhibits fifteen or more different enzymes. Of those enzymes, one stands out with potential for reducing age-related disease. AMP-activated protein kinase (AMPK) has shown to increase life span of nematodes and prevent obesity in mice. Although Resveratrol has not been proven to extend the life-span of mammals at the current doses tested, Resveratrol could be used to access some of the same molecular pathways that CR does. Several examples would include diet induced obesity, some cancers, cardiovascular disease, and neurodegenerative diseases.
While Resveratrol has not been proven to increase life span, Rapamycin has shown much more promise. Rapamycin is shown to increase longevity by inhibiting the target of rapamycin kinase (TOR) the same way CR does. Study systems including yeast, nematodes, flies, and mammals, have shown that reduction of TOR signaling will result in an increased life span. Additionally, Rapamycin has similar effects of Resveratrol in protecting against several cancers, cardiovascular, and neurodegenerative diseases. Rapamycin also has been shown to act as an immunosuppressant, however more testing is needed to show if the life extending dose comes at the cost of an impaired immune system.
Resveratrol and Rapamycin have both shown protection against cancers, cardiovascular disease, and neurodegenerative diseases in multiple study systems. Rapamycin looks to have more potential in life span extension than Resveratrol, but may come at a price of immune system impairment. Clinical trials are now being performed to see if Rapamycin or Resveratrol will have anti-aging effects in humans.
Other attempts to create anti-aging drugs have taken different research paths. One notable direction of research has been research into the possibility of using the enzyme telomerase in order to counter the process of telomere shortening. However, there are potential dangers in this, since some research has also linked telomerase to cancer and to tumor growth and formation.
Future advances in nanomedicine could give rise to life extension through the repair of many processes thought to be responsible for aging. K. Eric Drexler, one of the founders of nanotechnology, postulated cell repair machines, including ones operating within cells and utilizing as yet hypothetical molecular computers, in his 1986 book Engines of Creation. Raymond Kurzweil, a futurist and transhumanist, stated in his book The Singularity Is Near that he believes that advanced medical nanorobotics could completely remedy the effects of aging by 2030.
Cloning and body part replacement
Some life extensionists suggest that therapeutic cloning and stem cell research could one day provide a way to generate cells, body parts, or even entire bodies (generally referred to as reproductive cloning) that would be genetically identical to a prospective patient. Recently, the US Department of Defense initiated a program to research the possibility of growing human body parts on mice. Complex biological structures, such as mammalian joints and limbs, have not yet been replicated. Dog and primate brain transplantation experiments were conducted in the mid-20th century but failed due to rejection and the inability to restore nerve connections. As of 2006, the implantation of bio-engineered bladders grown from patients' own cells has proven to be a viable treatment for bladder disease. Proponents of body part replacement and cloning contend that the required biotechnologies are likely to appear earlier than other life-extension technologies.
The use of human stem cells, particularly embryonic stem cells, is controversial. Opponents' objections generally are based on interpretations of religious teachings or ethical considerations. Proponents of stem cell research point out that cells are routinely formed and destroyed in a variety of contexts. Use of stem cells taken from the umbilical cord or parts of the adult body may not provoke controversy.
The controversies over cloning are similar, except general public opinion in most countries stands in opposition to reproductive cloning. Some proponents of therapeutic cloning predict the production of whole bodies, lacking consciousness, for eventual brain transplantation.
For cryonicists (advocates of cryopreservation), storing the body at low temperatures after death may provide an "ambulance" into a future in which advanced medical technologies may allow resuscitation and repair. They speculate cryogenic temperatures will minimize changes in biological tissue for many years, giving the medical community ample time to cure all disease, rejuvenate the aged and repair any damage that is caused by the cryopreservation process.
Many cryonicists do not believe that legal death is "real death" because stoppage of heartbeat and breathing—the usual medical criteria for legal death—occur before biological death of cells and tissues of the body. Even at room temperature, cells may take hours to die and days to decompose. Although neurological damage occurs within 4–6 minutes of cardiac arrest, the irreversible neurodegenerative processes do not manifest for hours. Cryonicists state that rapid cooling and cardio-pulmonary support applied immediately after certification of death can preserve cells and tissues for long-term preservation at cryogenic temperatures. People, particularly children, have survived up to an hour without heartbeat after submersion in ice water. In one case, full recovery was reported after 45 minutes underwater. To facilitate rapid preservation of cells and tissue, cryonics "standby teams" are available to wait by the bedside of patients who are to be cryopreserved to apply cooling and cardio-pulmonary support as soon as possible after declaration of death.
No mammal has been successfully cryopreserved and brought back to life, with the exception of frozen human embryos. Resuscitation of a postembryonic human from cryonics is not possible with current science. Some scientists still support the idea based on their expectations of the capabilities of future science.
Strategies for Engineered Negligible Senescence (SENS)
Another proposed life extension technology would combine existing and predicted future biochemical and genetic techniques. SENS proposes that rejuvenation may be obtained by removing aging damage via the use of stem cells and tissue engineering, removal of telomere-lengthening machinery, allotopic expression of mitochondrial proteins, targeted ablation of cells, immunotherapeutic clearance, and novel lysosomal hydrolases.
While many biogerontologists find these ideas "worthy of discussion" and SENS conferences feature important research in the field, some contend that the alleged benefits are too speculative given the current state of technology, referring to it as "fantasy rather than science".
Gene therapy, in which nucleic acid polymers are delivered as a drug and are either expressed as proteins, interfere with the expression of proteins, or correct genetic mutations, has been proposed as a future strategy to prevent aging.
A large array of genetic modifications have been found to increase lifespan in model organisms such as yeast, nematode worms, fruit flies, and mice. As of 2013, the longest extension of life caused by a single gene manipulation was roughly 150% in mice and 10-fold in nematode worms.
In The Selfish Gene, Richard Dawkins describes an approach to life-extension that involves "fooling genes" into thinking the body is young. Dawkins attributes inspiration for this idea to Peter Medawar. The basic idea is that our bodies are composed of genes that activate throughout our lifetimes, some when we are young and others when we are older. Presumably, these genes are activated by environmental factors, and the changes caused by these genes activating can be lethal. It is a statistical certainty that we possess more lethal genes that activate in later life than in early life. Therefore, to extend life, we should be able to prevent these genes from switching on, and we should be able to do so by "identifying changes in the internal chemical environment of a body that take place during aging... and by simulating the superficial chemical properties of a young body".
Reversal of informational entropy
According to some lines of thinking, the ageing process is routed into a basic reduction of biological complexity, and thus loss of information. In order to reverse this loss, gerontologist Marios Kyriazis suggested that it is necessary to increase input of actionable and meaningful information both individually (into individual brains), and collectively (into societal systems). This technique enhances overall biological function through up-regulation of immune, hormonal, antioxidant and other parameters, resulting in improved age-repair mechanisms. Working in parallel with natural evolutionary mechanisms that can facilitate survival through increased fitness, Kyriazis claims that the technique may lead to a reduction of the rate of death as a function of age, i.e. indefinite lifespan.
One hypothetical future strategy that, as some suggest, "eliminates" the complications related to a physical body, involves the copying or transferring (e.g. by progressively replacing neurons with transistors) of a conscious mind from a biological brain to a non-biological computer system or computational device. The basic idea is to scan the structure of a particular brain in detail, and then construct a software model of it that is so faithful to the original that, when run on appropriate hardware, it will behave in essentially the same way as the original brain. Whether or not an exact copy of one's mind constitutes actual life extension is matter of debate.
History of the life extension movement
In 1970, the American Aging Association was formed under the impetus of Denham Harman, originator of the free radical theory of aging. Harman wanted an organization of biogerontologists that was devoted to research and to the sharing of information among scientists interested in extending human lifespan.
In 1976, futurists Joel Kurtzman and Philip Gordon wrote No More Dying. The Conquest Of Aging And The Extension Of Human Life, (ISBN 0-440-36247-4) the first popular book on research to extend human lifespan. Subsequently, Kurtzman was invited to testify before the House Select Committee on Aging, chaired by Claude Pepper of Florida, to discuss the impact of life extension on the Social Security system.
Saul Kent published The Life Extension Revolution (ISBN 0-688-03580-9) in 1980 and created a nutraceutical firm called the Life Extension Foundation, a non-profit organization that promotes dietary supplements. The Life Extension Foundation publishes a periodical called Life Extension Magazine. The 1982 bestselling book Life Extension: A Practical Scientific Approach (ISBN 0-446-51229-X) by Durk Pearson and Sandy Shaw further popularized the phrase "life extension".
In 1983, Roy Walford, a life-extensionist and gerontologist, published a popular book called Maximum Lifespan. In 1988, Walford and his student Richard Weindruch summarized their research into the ability of calorie restriction to extend the lifespan of rodents in The Retardation of Aging and Disease by Dietary Restriction (ISBN 0-398-05496-7). It had been known since the work of Clive McCay in the 1930s that calorie restriction can extend the maximum lifespan of rodents. But it was the work of Walford and Weindruch that gave detailed scientific grounding to that knowledge. Walford's personal interest in life extension motivated his scientific work and he practiced calorie restriction himself. Walford died at the age of 80 from complications caused by amyotrophic lateral sclerosis.
Money generated by the non-profit Life Extension Foundation allowed Saul Kent to finance the Alcor Life Extension Foundation, the world's largest cryonics organization. The cryonics movement had been launched in 1962 by Robert Ettinger's book, The Prospect of Immortality. In the 1960s, Saul Kent had been a co-founder of the Cryonics Society of New York. Alcor gained national prominence when baseball star Ted Williams was cryonically preserved by Alcor in 2002 and a family dispute arose as to whether Williams had really wanted to be cryopreserved.
Regulatory and legal struggles between the Food and Drug Administration (FDA) and the Life Extension Foundation included seizure of merchandise and court action. In 1991, Saul Kent and Bill Faloon, the principals of the Foundation, were jailed. The LEF accused the FDA of perpetrating a "Holocaust" and "seeking gestapo-like power" through its regulation of drugs and marketing claims.
In 2003, Doubleday published "The Immortal Cell: One Scientist's Quest to Solve the Mystery of Human Aging," by Michael D. West. West emphasised the potential role of embryonic stem cells in life extension.
In 1991, the American Academy of Anti-Aging Medicine (A4M) was formed as a non-profit organization to create what it considered an anti-aging medical specialty distinct from geriatrics, and to hold trade shows for physicians interested in anti-aging medicine. The A4M trains doctors in anti-aging medicine and publicly promotes the field of anti-aging research. It has about 26,000 members, of whom about 97% are doctors and scientists. The American Board of Medical Specialties recognizes neither anti-aging medicine nor the A4M's professional standing.
In 2003, Aubrey de Grey and David Gobel formed the Methuselah Foundation, which gives financial grants to anti-aging research projects. In 2009, de Grey and several others founded the SENS Research Foundation, a California-based scientific research organization which conducts research into aging and funds other anti-aging research projects at various universities. In 2013, Google announced Calico, a new company based in San Francisco that will harness new technologies to increase scientific understanding of the biology of aging. It is led by Arthur D. Levinson, and its research team includes scientists such as Hal V. Barron, David Botstein, and Cynthia Kenyon. In 2014, biologist Craig Venter founded Human Longevity Inc., a company dedicated to scientific research to end aging through genomics and cell therapy. It subsequently began building the a human genotype, microbiome, and phenotype database in the world to aid in its research.
Aside from private initiatives, aging research is being conducted in university laboratories, and includes universities such as Harvard and UCLA. University researchers have made a number of breakthroughs in extending the lives of mice and insects by reversing certain aspects of aging.
Ethics and politics of life extension
Though many scientists state that life extension and radical life extension are possible, there are still no international or national programs focused on radical life extension. There are political forces staying for and against life extension. By 2012, in Russia, the United States, Israel, and the Netherlands, the Longevity political parties started. They aimed to provide political support to radical life extension research and technologies, and ensure the fastest possible and at the same time soft transition of society to the next step - life without aging and with radical life extension, and to provide access to such technologies to most currently living people. 
Leon Kass (chairman of the US President's Council on Bioethics from 2001 to 2005) has questioned whether potential exacerbation of overpopulation problems would make life extension unethical. He states his opposition to life extension with the words:
"simply to covet a prolonged life span for ourselves is both a sign and a cause of our failure to open ourselves to procreation and to any higher purpose ... [The] desire to prolong youthfulness is not only a childish desire to eat one's life and keep it; it is also an expression of a childish and narcissistic wish incompatible with devotion to posterity."
John Harris, former editor-in-chief of the Journal of Medical Ethics, argues that as long as life is worth living, according to the person himself, we have a powerful moral imperative to save the life and thus to develop and offer life extension therapies to those who want them.
Transhumanist philosopher Nick Bostrom has argued that any technological advances in life extension must be equitably distributed and not restricted to a privileged few. In an extended metaphor entitled "The Fable of the Dragon-Tyrant", Bostrom envisions death as a monstrous dragon who demands human sacrifices. In the fable, after a lengthy debate between those who believe the dragon is a fact of life and those who believe the dragon can and should be destroyed, the dragon is finally killed. Bostrom argues that political inaction allowed many preventable human deaths to occur.
Aging as a disease
Most mainstream medical organizations and practitioners do not consider aging to be a disease. David Sinclair says: "I don't see aging as a disease, but as a collection of quite predictable diseases caused by the deterioration of the body". The two main arguments used are that aging is both inevitable and universal while diseases are not. However not everyone agrees. Harry R. Moody, Director of Academic Affairs for AARP, notes that what is normal and what is disease strongly depends on a historical context. David Gems, Assistant Director of the Institute of Healthy Ageing, strongly argues that aging should be viewed as a disease. In response to the universality of aging, David Gems notes that it is as misleading as arguing that Basenji are not dogs because they do not bark. Because of the universality of aging he calls it a 'special sort of disease'. Robert M. Perlman, coined the terms ‘aging syndrome’ and ‘disease complex’ in 1954 to describe aging.
The discussion whether aging should be viewed as a disease or not has important implications. It would stimulate pharmaceutical companies to develop life extension therapies and in the United States of America, it would also increase the regulation of the anti-aging market by the FDA. Anti-aging now falls under the regulations for cosmetic medicine which are less tight than those for drugs.
- Biological Aging Measurement. Clinical Applications. Ward Dean, MD. The Center for Bio-Gerontology. 1988. 426 pp. ISBN 0-937777-00-5
- The Biology of Life Span: A Quantitative Approach. Leonid A. Gavrilov & Natalia S. Gavrilova (1991), New York: Harwood Academic Publisher, ISBN 3-7186-4983-7
- Brain Boosters. Foods And Drugs That Make You Smarter. (A quote from the book: "It's hard to distinguish between the health and anti-aging uses of the smart drugs and nutrients.") Beverly Potter & Sebastian Orfali. Ronin Publishing. 1993. 257 pages. ISBN 0-914171-65-8
- Brain Fitness. Anti-Aging Strategies To Fight Alzheimer's Disease, Supercharge Your Memory, Sharpen Your Intelligence, De-Stress Your Mind, Control Mood Swings, and Much More... Robert Goldman, MD, DO, PhD, With Ronald Klatz, MD, DO, and Liza Berger. Doubleday. 1995. 346 pp. ISBN 0-385-48869-6
- The Directory of Life Extension Supplements. Life Extension Foundation. Published annually.
- Fantastic Voyage: The Science Behind Radical Life Extension Raymond Kurzweil and Terry Grossman, MD. Rodale. 2004. 452 pp. ISBN 1-57954-954-3
- 50 Simple Ways To Live A Longer Life: Everyday Techniques From The Forefront Of Science. Suzanne Bohan and Glenn Thompson. Sourcebooks. 2005. 287 pages. ISBN 1-4022-0375-6
- Formula for Life. The Definitive Book on Correct Nutrition, Anti-Oxidants and Vitamins, Disease Prevention, and Longevity. Eberhard Kronhausen, EdD, and Phyllis Kronhausen EdD, with Harry B. Demopoulos, MD. William Morrow and Company. 1989. 622 pages. ISBN 0-688-09426-0
- How To Live Longer And Feel Better. Linus Pauling. W.H. Freeman and Company. 1986. 413 pages. ISBN 0-380-70289-4
- The Immortal Cell, by Michael D. West, Doubleday (2003) ISBN 978-0-385-50928-2
- Life Extension. A Practical Scientific Approach. Adding Years to Your Life and Life to Your Years. Durk Pearson and Sandy Shaw. Warner Books. 1982. Hardcover, 858 pp. ISBN 0-446-51229-X
- The Life Extension Companion. The Latest Breakthroughs in Health Science. Durk Pearson and Sandy Shaw. Warner Books. 1984. Hardcover, 430 pages. ISBN 0-446-51277-X
- The Life Extension Revolution: The Definitive Guide to Better Health, Longer Life, and Physical Immortality. Saul Kent. 1980. Hard Cover. ISBN 0-688-03580-9
- The Life Extension Revolution: The New Science of Growing Older Without Aging. Philip Lee Miller and Monica Reinagel. Bantam. 2005. Hardcover, (416 pages). ISBN 0-553-80353-0
- The Life Extension Weight Loss Programme. Durk Pearson and Sandy Shaw.
- LifeSpan-Plus. 900 Natural Techniques To Live Longer. Rejuvenate Your Heart; Stay Infection-Free; Prevent a Stroke; Reduce Stress; Control Your Blood Pressure; Strengthen Your Bones; Eliminate Body Toxins. By the editors of Prevention Magazine. Rodale. 1990. Hardcover, 422 pages. ISBN 0-87857-908-7
- Live Longer Now. The First One Hundred Years Of Your Life. Jon N. Leanard, Jack L. Hofer, and Nathan Pritikin. Grosset and Dunlap. 1974 (predates the life extension movement, and therefore lacks megadosing recommendations.) 232 pages. ISBN 0-441-48514-6
- The Long Tomorrow. Michael Rose. Oxford University Press. 2005. ISBN 0-19-517939-0
- Merchants of Immortality. Chasing The Dream Of Human Life Extension. Stephen S. Hall. Houghton Mifflin Company. 2003. 439 pp. ISBN 0-618-49221-6
- Mind Food and Smart Pills. How To Increase Your Intelligence and Prevent Brain Aging. Ross Pelton. 1986. 170 pp. ISBN 0-936809-00-0
- No More Dying. The Conquest Of Aging And The Extension Of Human Life. Joel Kurtzman and Phillip Gordon. Dell. 1976. 252 pages. ISBN 0-440-36247-4
- Prevention's The Sugar Solution. Edited by Sari Harrar, Prevention Health News Editor. Rodale. 2005. Hardcover, 406 pages. ISBN 1-57954-912-8
- Secrets of Life Extension. How to halt or reverse the aging process and live a long and healthy life. You can extend the rest of your life. All the new scientific breakthroughs John A. Mann. Bantam Books. 1980. 296 pages. ISBN 0-553-23450-1
- Nutrition Against Disease. Roger J. Williams. Pitman Publishing Corporation. 1971 (predates megadosing). 370 pages. ISBN 0-273-31850-0
- Smart Drugs & Nutrients. How To Improve Your Membory And Increase Your Intelligence Using The Latest Discoveries In Neuroscience. (Many of the substances in this book have life-extending or cell regenerating effects.) Ward Dean, MD and Joh Morgenthaler. B&J Publications. 1990. 222 pp. ISBN 0-9627418-9-2
- Smart Drugs II: The Next Generation: New Drugs and Nutrients to Improve Your Memory and Increase Your Intelligence. Ward Dean (MD), John Morgenthaler, Steven Wm Fowkes. Smart Publications. 1993. 287 pages. ISBN 0-9627418-7-6
- Stop Aging Now! The Ultimate Plan For Staying Young & Reversing The Aging Process. Based On Cutting-Edge Research Revealing The Amazing Anti-aging Powers Of Supplements, Herbs, & Food. Jean Carper. Harper Perennial. 1995. 372 pp. ISBN 0-06-098500-3
- Stop the FDA. Save Your Health Freedom. Articles by Linus Pauling, PhD; Abram Hoffer, MD; Ward Dean, MD; Senator Orrin Hatch; Durk Pearson and Sandy Shaw; and many more. (Many essays on health politics, by various leaders of the Life Extension Movement). Edited by John Morgenthaler & Steven Wm. Fowkes. Health Freedom Publications. 1992. 186 pp. ISBN 0-9627418-8-4
- The Wrinkle Cure. The All-Natural Formula for Stopping Time. Unlock the Power of Cosmeceuticals for Supple, Youthful Skin. Nicholas Perricone, MD. Rodale. 2000. Hardcover, 208 pages. ISBN 1-57954-237-9
- Your Personal Life-Extension Program. A Practical Guide to the New Science That Can Make You Stronger, Smarter, Sexier, More Energetic, and More Youthful. Saul Kent. Morrow. 1985. Hardcover, 384 pages. ISBN 0-688-00629-9
- "agerasia". Oxford English Dictionary (3rd ed.). Oxford University Press. September 2005.
- Japsen, Bruce (15 June 2009). "AMA report questions science behind using hormones as anti-aging treatment". The Chicago Tribune. Retrieved 17 July 2009.
- Holliday, R (April 2009). "The extreme arrogance of anti-aging medicine". Biogerontology volume=10 issue=2 pages=223–8 date=April 2009 pmid=18726707 10 (2): 223–8. doi:10.1007/s10522-008-9170-6. PMID 18726707.
- Olshansky, SJ; Hayflick, L; Carnes, BA (1 August 2002). "Position statement on human aging". The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 57 (8): B292–7. doi:10.1093/gerona/57.8.B292. PMID 12145354.[dead link]
- Warner H, Anderson J, Austad S, et al. (November 2005). "Science fact and the SENS agenda. What can we reasonably expect from ageing research?". EMBO Reports 6 (11): 1006–8. doi:10.1038/sj.embor.7400555. PMC 1371037. PMID 16264422.
- Marziali, Carl (7 December 2010). "Reaching Toward the Fountain of Youth". USC Trojan Family Magazine. Retrieved 7 December 2010.
- Newmark PA, Sánchez Alvarado A (2002). "Not your father's planarian: a classic model enters the era of functional genomics". Nat Rev Genet 3 (3): 210–219. doi:10.1038/nrg759. PMID 11972158.
- Bavestrello Giorgio, Sommer Christian, Sarà Michele (1992). "Bi-directional conversion in Turritopsis nutricula (Hydrozoa)". Scientia Marina 56 (2–3): 137–140.
- Martínez DE (May 1998). "Mortality patterns suggest lack of senescence in hydra" 33 (3). pp. 217–25. doi:10.1016/S0531-5565(97)00113-7. PMID 9615920.
- Petralia RS, Mattson MP, Yao PJ (2014). "Aging and longevity in the simplest animals and the quest for immortality". Ageing Res Rev 16: 66–82. doi:10.1016/j.arr.2014.05.003.
- "Superlongevity Without Overpopulation". Fight Aging!.
- "Living to 120 and Beyond: Americans’ Views on Aging, Medical Advances and Radical Life Extension". Pew Research Center's Religion & Public Life Project. 6 August 2013.
- "Peter Singer on Should We Live to 1,000? - Project Syndicate". Project Syndicate.
- de Magalhães JP (2014). "The scientific quest for lasting youth: prospects for curing aging". Rejuvenation Res 17 (5): 458–67. doi:10.1089/rej.2014.1580. PMID 25132068.
- López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013). "The hallmarks of aging". Cell 153 (6): 1194–1217. doi:10.1016/j.cell.2013.05.039. PMID 23746838.
- Halliwell B, Gutteridge JMC (2007). Free Radicals in Biology and Medicine. Oxford University Press, USA, ISBN 019856869X, ISBN 978-0198568698
- Holmes GE, Bernstein C, Bernstein H (September 1992). "Oxidative and other DNA damages as the basis of aging: a review" 275 (3-6). pp. 305–15. doi:10.1016/0921-8734(92)90034-M. PMID 1383772.
- "MGI-Mouse Facts".
- "What Causes Aging? Damage-Based Theories of Aging".
- Verdaguer E, Junyent F, Folch J, Beas-Zarate C, Auladell C, Pallàs M, Camins A (2012). "Aging biology: a new frontier for drug discovery". Expert Opin Drug Discov 7 (3): 217–229. doi:10.1517/17460441.2012.660144. PMID 22468953.
- Rauser CL, Mueller LD, Rose MR (2006). "The evolution of late life". Ageing Res Rev. 5 (1): 14–32. doi:10.1016/j.arr.2005.06.003. PMID 16085467.
- Stearns SC, Ackermann M, Doebeli M, Kaiser M (2000). "Experimental evolution of aging, growth, and reproduction in fruitflies". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3309–3313. doi:10.1073/pnas.060289597. PMID 10716732.
- Rando TA, Chang HY (2012). "Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock". Cell 148 (1-2): 46–57. doi:10.1016/j.cell.2012.01.003. PMID 22265401.
- Johnson AA, Akman K, Calimport SR, Wuttke D, Stolzing A, de Magalhães JP (2012). "The role of DNA methylation in aging, rejuvenation, and age-related disease". Rejuvenation Res 15 (5): 483–494. doi:10.1089/rej.2012.1324. PMID 23098078.
- Schumacher, B; van der Pluijm, I; Moorhouse, MJ; et al. (2008). Kim, Stuart K., ed. "Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms". PLoS Genetics 4 (8): e1000161. doi:10.1371/journal.pgen.1000161. PMC 2493043. PMID 18704162.
- Chen, J; Velalar, CN; Ruan, R (August 2008). "Identifying the changes in gene profiles regulating the amelioration of age-related oxidative damages in kidney tissue of rats by the intervention of adult-onset calorie restriction". Rejuvenation Research 11 (4): 757–63. doi:10.1089/rej.2008.0718. PMID 18710334.
- Holloszy, J. O.,; Fontana, L. (2007). "Caloric restriction in humans. Experimental gerontology,". Experimental Gerontology 42 (8): 707–712. doi:10.1016/j.exger.2007.03.009. PMID 17482403.
- Bjelakovic Goran, Nikolova Dimitrinka, Lotte Gluud Lise, Simonetti Rosa G., Gluud Christian (2007). "Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention, a Systematic Review and Meta-analysis". JAMA 297: 842–857. doi:10.1001/jama.297.8.842.
- "Resveratrol Longevity Science Makes Dramatic U-Turn, But Resveratrol Supplements Remain Unchanged" (Press release). Resveratrol Partners. 10 September 2008. Retrieved 17 July 2009.
- Valenzano, DR; Terzibasi, E; Genade, T; Cattaneo, A; Domenici, L; Cellerino, A (February 2006). "Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate". Current Biology 16 (3): 296–300. doi:10.1016/j.cub.2005.12.038. PMID 16461283.
- Schroeder, HA; Mitchener, M (1 November 1971). "Selenium and tellurium in rats: effect on growth, survival and tumors". The Journal of Nutrition 101 (11): 1531–40. PMID 5124041.
- Mocchegiani, E; Santarelli, L; Tibaldi, A; et al. (June 1998). "Presence of links between zinc and melatonin during the circadian cycle in old mice: effects on thymic endocrine activity and on the survival". Journal of Neuroimmunology 86 (2): 111–22. doi:10.1016/S0165-5728(97)00253-1. PMID 9663556.
- Mocchegiani, E; Santarelli, L; Muzzioli, M; Fabris, N (September 1995). "Reversibility of the thymic involution and of age-related peripheral immune dysfunctions by zinc supplementation in old mice". International Journal of Immunopharmacology 17 (9): 703–18. doi:10.1016/0192-0561(95)00059-B. PMID 8582782.
- Anisimov, VN; Berstein, LM; Egormin, PA; et al. (2005). "Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice". Experimental Gerontology 40 (8–9): 685–93. doi:10.1016/j.exger.2005.07.007. PMID 16125352.
- Mishra and Joshi. (2011). "Jiao Gu Lan (Gynostemma pentaphyllum): The Chinese Rasayan". International Journal of Research in Pharmaceutical and Biomedical Sciences.
- S. Priyadarshini et al. (2010). "Increase in Drosophila melanogaster longevity due to rasayana diet: Preliminary results". J Ayurveda Integr Med 1 (2): 114–119. doi:10.4103/0975-9476.65085. PMC 3151378. PMID 21836798.
- Alexopoulou O, Abs R, Maiter D (2010). "Treatment of adult growth hormone deficiency: who, why and how? A review". Acta Clinica Belgica 65 (1): 13–22. doi:10.1179/acb.2010.002. PMID 20373593.
- Ahmad AM, Hopkins MT, Thomas J, Ibrahim H, Fraser WD, Vora JP (June 2001). "Body composition and quality of life in adults with growth hormone deficiency; effects of low-dose growth hormone replacement". Clinical Endocrinology 54 (6): 709–17. doi:10.1046/j.1365-2265.2001.01275.x. PMID 11422104.
- Savine R, Sönksen P (2000). "Growth hormone - hormone replacement for the somatopause?". Hormone Research 53 (Suppl 3): 37–41. doi:10.1159/000023531. PMID 10971102.
- Khansari, DN; Gustad, T (January 1991). "Effects of long-term, low-dose growth hormone therapy on immune function and life expectancy of mice". Mechanisms of Ageing and Development 57 (1): 87–100. doi:10.1016/0047-6374(91)90026-V. PMID 2002700.
- Bonkowski, MS; Pamenter, RW; Rocha, JS; Masternak, MM; Panici, JA; Bartke, A (1 June 2006). "Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics". The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 61 (6): 562–7. doi:10.1093/gerona/61.6.562. PMID 16799137.[dead link]
- Wade, Nicholas (16 February 2011). "Ecuadorean Villagers May Hold Secret to Longevity". The New York Times.
- Sobh Rana, Martin Brett A. S. (2011). "Feedback Information and Consumer Motivation. The Moderating Role of Positive and Negative Reference Values in Self-Regulation" (PDF). European Journal of Marketing 45 (6): 963–986. doi:10.1108/03090561111119976.
- Rozalyn M. Anderson, Dhanansayan Shanmuganayagam1,and Richard Weindruchhtt "Caloric Restriction and Aging: Studies in Mice and Monkeys", Journal of Toxicological Pharmacology. http://tpx.sagepub.com/content/37/1/47
- Harrison DE, Strong R, Sharp ZD et al. (2009). "Rapamycin fed late in life extends lifespan in genetically heterogeneous mice". Nature 460: 392–5. doi:10.1038/nature08221.
- Dhahbi JM, Mote PL, Fahy GM, Spindler SR (Nov 2005). "Identification of Potential Caloric Restriction Mimetics by Microarray Profiling". Physiological Genomics 23 (3): 343–50. doi:10.1152/physiolgenomics.00069.2005. PMID 16189280.
- Barger Jamie L., Kayo Tsuyoshi, Vann James M. et al.. "A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice". PLOS ONE. doi:10.1371/journal.pone.0002264.
- Kaeberlein, Matt (2010). "Resveratrol and rapamycin:are they anti-aging drugs?". BioEssays 32 (2): 96–99. doi:10.1002/bies.200900171. PMID 20091754.
- Redman LM, Heilbronn LK, Martin CK et al. (2009). "Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss". PLOS ONE 4: e4377. doi:10.1371/journal.pone.0004377.
- Holloszy JO, Fontana L (2007). "Caloric restriction in humans". Exp Gerontol 42: 709–12. doi:10.1016/j.exger.2007.03.009.
- Mattison Julie A. et al. (2012). "Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study". Nature 489 (7415): 318–321. doi:10.1038/nature11432.
- Howitz KT, Bitterman KJ, Cohen HY et al. (2003). "Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan". Nature 425 (6954): 191–6. doi:10.1038/nature01960. PMID 12939617.
- Bass TM, Weinkove D, Houthoofd K et al. (2007). "Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans". Mech Ageing Dev 128 (10): 546–52. doi:10.1016/j.mad.2007.07.007. PMID 17875315.
- Beher D, Wu J, Cumine S et al. (2009). "Resveratrol is not a direct activator of SIRT1 enzyme activity". Chem Biol Drug Des 74: 619–24. doi:10.1111/j.1747-0285.2009.00901.x.
- Borra MT, Smith BC, Denu JM (2005). "Mechanism of human SIRT1 activation by resveratrol". J Biol Chem 280: 17187–95. doi:10.1074/jbc.m501250200.
- Kaeberlein M, McDonagh T, Heltweg B et al. (2005). "Substrate-specific activation of sirtuins by resveratrol". J Biol Chem 280: 17038–45. doi:10.1074/jbc.m500655200.
- Pirola L, Frojdo S (2008). "Resveratrol: one molecule, many targets". IUBMB Life 60: 323–32. doi:10.1002/iub.47.
- Yang J, Maika S, Craddock L et al. (2008). "Chronic activation of AMPactivated protein kinase-alpha1 in liver leads to decreased adiposity in mice". Biochem Biophys Res Commun 370: 248–53. doi:10.1016/j.bbrc.2008.03.094.
- Markus MA, Morris BJ (2008). "Resveratrol in prevention and treatment of common clinical conditions of aging". Clin Interv Aging 3 (2): 331–9. PMID 18686754.
- Kaeberlein M, Kapahi P (2009). "Aging is RSKy business". Science 326: 55–6. doi:10.1126/science.1181034.
- Stanfel MN, Shamieh LS, Kaeberlein M et al. (2009). "The TOR pathway comes of age". Biochim Biophys Acta 1790: 1067–74. doi:10.1016/j.bbagen.2009.06.007.
- "Telomeres and Telomerase Basic Science Implications for Aging". American Geriatrics Society 49 (8): 1105–1109. doi:10.1046/j.1532-5415.2001.49217.x.
- Elizabeth H. Blackburn. "Telomerase and Cancer". Molecular Cancer Research.
- Kurzweil, Ray (2005). The Singularity Is Near. New York City: Viking Press. ISBN 978-0-670-03384-3. OCLC 57201348.[page needed]
- Melanson, Donald (April 22, 2008). "DoD establishes institute tasked with regrowing body parts". Engadget. Retrieved June 29, 2010.
- Khamsi, Roxanne (April 4, 2006). "Bio-engineered bladders successful in patients". New Scientist. Retrieved January 26, 2011.
- White, Christine (19 August 2005). "Umbilical stem cell breakthrough". The Australian. Retrieved 17 July 2009.
- David Segal for the New York Times. 1 June 2013 This Man Is Not a Cyborg. Yet.
- Garcia, JH; Liu, KF; Ho, KL (1 April 1995). "Neuronal necrosis after middle cerebral artery occlusion in Wistar rats progresses at different time intervals in the caudoputamen and the cortex". Stroke 26 (4): 636–42; discussion 643. doi:10.1161/01.STR.26.4.636. PMID 7709411.
- Perk, L; Borger van de Burg, F; Berendsen, HH; van't Wout, JW (April 2002). "Full recovery after 45 min accidental submersion". Intensive Care Medicine 28 (4): 524. doi:10.1007/s00134-002-1245-2. PMID 11967613.
- "Comprehensive Member Standby". Retrieved 14 December 2010.
- "Scientists' Open Letter on Cryonics". Retrieved 17 July 2009.
- "Advances in Cryonics". Retrieved 14 December 2010.
- de Grey, Aubrey; Michael Rae (2007). Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime. New York City: St. Martin's Press. ISBN 978-0-312-36706-0. OCLC 132583222.[page needed]
- Pontin, Jason (July 11, 2006). "Is Defeating Aging Only A Dream?". Technology Review.
- Garreau, Joel (October 31, 2007). "Invincible Man". Washington Post.
- Fourth SENS Conference (2009). Over 140 Accepted Abstracts. Cambridge, England, September 3–7th, 2009.
- Kristen Fortney (2009). SENS4 Conference Coverage From Ouroboros. FightAging.org, September 4, 2009.
- Goya, Rodolfo G.; Federico Bolognani; Claudia B. Hereñú; Omar J. Rimoldi (2001-01-08). "Neuroendocrinology of Aging: The Potential of Gene Therapy as an Interventive Strategy". Gerontology 47 (168–173): 168. doi:10.1159/000052792.
- Rattan, S. I. S.; Singh, R. (2008-10-22). "Progress & Prospects: Gene therapy in aging". Gene Therapy 16 (3–9): 3–9. doi:10.1038/gt.2008.166. PMID 19005494. Retrieved 2009-11-18.
- Tacutu R, Craig T, Budovsky A, Wuttke D, Lehmann G, Taranukha D, Costa J, Fraifeld VE, de Magalhães JP. Human Ageing Genomic Resources: integrated databases and tools for the biology and genetics of ageing" Nucleic Acids Res 2013; 41:D1027-33. doi:10.1093/nar/gks1155 PMID 23193293
- Dawkins, Richard (2006) . The Selfish Gene. New York: Oxford University Press. pp. 41–42. ISBN 978-0-19-929115-1.
- Dawkins, Richard (2006) . The Selfish Gene. New York: Oxford University Press. p. 42. ISBN 978-0-19-929115-1.
- "Aging as a Process of Complexity Loss".
- "h+ Magazine - The Longevity of Real Human Avatars - h+ Magazine". h+ Magazine.
- "The Myth of the Longevity Elixir".
- Sandberg, Anders; Boström, Nick (2008). Whole Brain Emulation: A Roadmap. Technical Report #2008‐3. Future of Humanity Institute, Oxford University. Retrieved 7 March 2013.
The basic idea is to take a particular brain, scan its structure in detail, and construct a software model of it that is so faithful to the original that, when run on appropriate hardware, it will behave in essentially the same way as the original brain.
- Clevenger, Ty (Summer 2000). "Internet pharmacies: cyberspace versus the regulatory state". Journal of Law and Health. Retrieved 17 July 2009.
- The immortal Cell: One Scientist's Quest to Solve the Mystery of Human Aging. Google Books. Retrieved 2003-0-16. Check date values in:
- "About A4M - Worldhealth.net Anti-Aging News".
- Kuczynski, Alex (12 April 1998). "Anti-Aging Potion Or Poison?". The New York Times. Retrieved 17 July 2009.
- Arion McNicoll, for CNN (3 October 2013). "How Google's Calico aims to fight aging and 'solve death'". CNN.
- "Google announces Calico, a new company focused on health and well-being".
- Human Longevity Inc. (4 March 2014). "Human Longevity Inc. (HLI) Launched to Promote Healthy Aging Using Advances in... -- SAN DIEGO, March 4, 2014 /PRNewswire/ --".
- Elizabeth Landau, CNN (5 May 2014). "Young blood makes old mice more youthful". CNN.
- Stuart Wolpert. "UCLA biologists delay the aging process by ‘remote control’".
- "Australian and US scientists reverse ageing in mice, humans could be next". ABC News.
- "Scientists' Open Letter on Aging". Imminst.org. Retrieved 2012-10-07.
- Posted by Reason. "A Single-Issue Political Party for Longevity Science". Fightaging.org. Retrieved 2012-10-07.
- "Google Translate". Translate.google.com. Retrieved 2012-10-07.
- Smith, Simon (3 December 2002). "Killing Immortality". Betterhumans. Archived from the original on 7 June 2004. Retrieved 17 July 2009.
- Kass, Leon (1985). Toward a more natural science: biology and human affairs. New York City: Free Press. p. 316. ISBN 978-0-02-918340-3. OCLC 11677465.
- Harris J. Enhancing Evolution: The ethical case for making better people. Princeton University Press, New Jersey, 2007.
- Sutherland, John (9 May 2006). "The ideas interview: Nick Bostrom". The Guardian (London). Retrieved 17 July 2009.
- Bostrom, N (May 2005). "The fable of the dragon tyrant". Journal of Medical Ethics 31 (5): 273–7. doi:10.1136/jme.2004.009035. PMC 1734155. PMID 15863685.
- Hayden EC (2007). "A new angle on 'old'". Nature 450 (7170): 603–603. doi:10.1038/450603a. PMID 18046373.
- Hamerman D. "Geriatric Bioscience: The link between aging&disease." The Johns Hopkins University Press, Maryland, 2007.
- Moody HR. "Who's afraid of life extension?" Generations. 2001/2; 25:33-37.
- Gems D (2011). "Aging: To Treat, or Not to Treat? The possibility of treating aging is not just an idle fantasy". American Scientist 99 (4): 278–80. doi:10.1511/2011.91.278.
- Gems D (2011). "Tragedy and delight: the ethics of decelerated ageing". Phil Trans R Soc B. 366: 108–112. doi:10.1098/rstb.2010.0288.
- Perlman RM (1954). "The aging syndrome". J Am Geriatr Soc. 2: 123–129.
- Mehlman MJ, Binstock RH, Juengst ET, Ponsaran RS, Whitehouse PJ. "Anti-aging medicine: can consumers be better protected? Gerontologist. 2004; 44:304-310.