Continuing where Stitch! The Movie left off, Lilo and Stitch are given the task of collecting the rest of Jumba's missing experiments, changing them from bad to good, and finding the one place where they truly belong. Meanwhile, the former Captain Gantu and his reluctant partner, Experiment 625 (later named Reuben), try to capture the experiments for the imprisoned Dr. Hämsterviel.
Running for two seasons, it had a total of 65 episodes.
007/Gigi (Voiced by Tress MacNeille) - Mertle's pet. Gigi is a Shih-Tzu like experiment and the place who truly belongs is with Mertle as her pet.
624/Angel (voiced by Tara Strong) - Stitch's main love interest. Angel is a pink pretty experiment who was designed to turn the good experiments evil with a siren song. She was caught by Gantu and she was rescued in Snafu.
221/Sparky (voiced by Frank Welker) - The first of Stitch's cousins that Stitch met. Sparky is a yellow experiment designed to create electric energy. His place where he truly belongs is in the old lighthouse to utilize his electric skills to generate light. Appeared in most episodes of the series.
Yuki, Elena and Teresa - Mertle's possé consists of Yuki (voiced by Lili Ishida), Elena (voiced by Jillian Henry) and Teresa (voiced by Kali Whitehurst). They usually travel in a group and seldom say anything other than a sarcastic "Yeah!" in unison when agreeing with Mertle on something.
Grand Councilwoman (voiced by Zoe Caldwell) - the leader of the Galaxy's ruling Federation, she is the one who banished Stitch in the first movie. She later agrees to let Lilo and Stitch become official experiment hunters in order to retrieve all of the remaining experiments.
Keoni Jameson (voiced by Shaun Fleming) - Keoni is a young, laid-back boy on whom Lilo has a crush. Lilo constantly tries to vie for his affections. He had a crush on Pleakley, whom he knows as Lilo's 'aunt', in the episode "Hunkahunka", but in "Nosy" he stated that he only had the crush for that one week. His father owns several businesses on Kauai. He has a friend who just happens to be a girl (not a girlfriend, though). This friend is first shown in "Hunkahunka" and later seen in "Morpholemew".
Mr. Jameson - (voiced by Bryan Cranston) Mr. Jameson is the father of Keoni and, on several occasions, Nani's employer. He owns several businesses around Kauai, including the Birds of Paradise Hotel.
Moses Puloki (voiced by Kunewa Mook) - the hula teacher of Lilo's school, where he teaches Lilo, Victoria, Mertle, Yuki, Elena and Teresa how to hula. He is very patient with his students and tolerates their antics. Lilo and her friends often call Moses Kumu, Hawaiian for teacher.
Officer Kaiiko - Officer Kaiiko is a police officer who knows Lilo well and occasionally tries to keep her out of trouble when she isn't accompanied by Nani. He appears in the episodes "Holio", "Bonnie & Clyde", "Snooty", and "Shush".
Victoria (voiced by Daveigh Chase and Alyson Stoner) - Lilo's new (human) best friend, whom she meets in the episode "Swapper". Throughout the episode, Lilo tries to prove to her she wasn't weird. But in the end, Victoria reveals she likes weird stuff so she and Lilo become best friends. Victoria is also in Lilo's Hula Class and owns Snooty (Experiment 277) as a pet. She appears in the episodes "Swapper", "Snooty," Slick", "Remmy", and "Wishy-Washy".
Mrs. Hasagawa (voiced by Amy Hill) - The little old lady who owns the fruit stand. Several experiments live with her.
Sunburned Ice Cream Tourist: (voiced by Frank Welker) - This is a running gag throughout the Lilo & Stitch franchise. Whenever he appears, The Sunburned Ice Cream Tourist drops his ice cream (presumably a mint-flavored ice cream from its color) from its cone before he can finish it. The Sunburned Ice Cream Tourist never has a spoken part in the series except saying "Whoa!" when he tripped over a pod. He also cries after suffering from 151 (Babyfier)'s effects. His real eyes can be seen in the episode "Swirly".