Linda B. Buck
|Linda Brown Buck|
January 29, 1947 |
Seattle, Washington, U.S.
|Institutions||Fred Hutchinson Cancer Research Center
University of Washington, Seattle
Howard Hughes Medical Institute
|Alma mater||University of Washington (B.S., 1975)
University of Texas Southwestern Medical Center at Dallas (Ph.D., 1980)
|Known for||Olfactory receptors|
|Notable awards||Takasago Award (1992)
Lewis S. Rosenstiel Award (1997)
Gairdner Foundation International Award (2003)
Nobel Prize in Physiology or Medicine (2004)
Linda Brown Buck (born January 29, 1947) is an American biologist best known for her work on the olfactory system. She was awarded the 2004 Nobel Prize in Physiology or Medicine, along with Richard Axel, for their work on olfactory receptors.
In their landmark paper published in 1991, Buck and Axel cloned olfactory receptors, showing that they belong to the family of G protein-coupled receptors. By analyzing rat DNA, they estimated that there were approximately one thousand different genes for olfactory receptors in the mammalian genome. This research opened the door to the genetic and molecular analysis of the mechanisms of olfaction. In their later work, Buck and Axel have shown that each olfactory receptor neuron remarkably only expresses one kind of olfactory receptor protein and that the input from all neurons expressing the same receptor is collected by a single dedicated glomerulus of the olfactory bulb.
Born in Seattle, Washington, Buck received her B.S. in psychology and microbiology in 1975 from the University of Washington, Seattle and her Ph.D. in immunology in 1980 from the University of Texas Southwestern Medical Center at Dallas. She did her post-doctoral work at Columbia University under Axel. In 1991 Buck became an assistant professor of neurobiology at Harvard University where she expanded her knowledge of the nervous system. Her primary research interest is on how pheromones and odors are detected in the nose and interpreted in the brain. She is a Full Member of the Basic Sciences Division at Fred Hutchinson Cancer Research Center, an Affiliate Professor of Physiology and Biophysics at the University of Washington, Seattle and an Investigator of the Howard Hughes Medical Institute. She was inducted into the National Academy of Sciences in 2004. Buck was elected a Fellow of the American Academy of Arts and Sciences in 2008. She also sits on the Selection Committee for Life Science and Medicine which chooses winners of the Shaw Prize.
- Buck L., Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 1991;65:175-87. doi:10.1016/0092-8674(91)90418-X PMID 1840504.
- "Facts & Figures". Harvard Medical School. Harvard College. Retrieved 7 November 2012.
- "Press Release: The 2004 Nobel Prize in Physiology or Medicine". Nobelprize.org. Retrieved 8 November 2012.
- "Linda B. Buck - Autobiography". NobelPrize.org. Retrieved 7 November 2012.
- "Book of Members, 1780-2010: Chapter B". American Academy of Arts and Sciences. Retrieved 7 April 2011.
- Webpage at Howard Hughes Medical Institute
- "Secrets of smell land Nobel Prize". BBC News. 4 October 2004. Retrieved 8 November 2012.
- Curriculum vitae of Linda Buck