Linda B. Buck
| Linda Brown Buck | |
|---|---|
 |
|
| Born | January 29, 1947 Seattle, Washington, U.S. |
| Nationality | American |
| Fields | Biologist |
| Institutions | Fred Hutchinson Cancer Research Center University of Washington, Seattle Howard Hughes Medical Institute Columbia University Harvard University[1] |
| Alma mater | University of Washington, Seattle |
| Known for | olfactory receptors |
| Notable awards | Nobel Prize in Physiology or Medicine (2004) |
Linda Brown Buck (born January 29, 1947) is an American biologist best known for her work on the olfactory system. She was awarded the 2004 Nobel Prize in Physiology or Medicine, along with Richard Axel, for their work on olfactory receptors.
In their landmark paper published in 1991, Buck and Axel cloned olfactory receptors, showing that they belong to the family of G protein-coupled receptors. By analyzing rat DNA, they estimated that there were approximately one thousand different genes for olfactory receptors in the mammalian genome. This research opened the door to the genetic and molecular analysis of the mechanisms of olfaction. In their later work, Buck and Axel have shown that each olfactory receptor neuron remarkably only expresses one kind of olfactory receptor protein and that the input from all neurons expressing the same receptor is collected by a single dedicated glomerulus of the olfactory bulb.
Born in Seattle, Washington, Buck received her B.S. in psychology and microbiology in 1975 from the University of Washington, Seattle and her Ph.D. in immunology in 1980 from the University of Texas Southwestern Medical Center at Dallas. She did her post-doctoral work at Columbia University under Axel. In 1991 Buck became an assistant professor of neurobiology at Harvard University where she expanded her knowledge of the nervous system.[2] Her primary research interest is on how pheromones and odors are detected in the nose and interpreted in the brain. She is a Full Member of the Basic Sciences Division at Fred Hutchinson Cancer Research Center, an Affiliate Professor of Physiology and Biophysics at the University of Washington, Seattle and an Investigator of the Howard Hughes Medical Institute. She was inducted into the National Academy of Sciences in 2004. Buck was elected a Fellow of the American Academy of Arts and Sciences in 2008.[3]
In 2010, Buck was forced to retract some of her publications because she was "unable to reproduce the key findings" of her experiments[4].
![[icon]](/wiki/File:Wiki_letter_w_cropped.svg){kind=small} |
This section requires expansion. |
[edit] See also
[edit] References
- ^ http://hms.harvard.edu/hms/facts.asp
- ^ http://nobelprize.org/nobel_prizes/medicine/laureates/2004/buck-autobio.html
- ^ "Book of Members, 1780-2010: Chapter B". American Academy of Arts and Sciences. http://www.amacad.org/publications/BookofMembers/ChapterB.pdf. Retrieved 7 April 2011.
- ^ http://classic.the-scientist.com/blog/display/57699/
- Buck L, Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 1991;65:175-87. doi:10.1016/0092-8674(91)90418-X
PMID 1840504.
[edit] External links
- Nobel Citation
- Webpage at the Fred Hutchinson Cancer Research Center
- Webpage at Howard Hughes Medical Institute
- BBC
- Curriculum vitae of Linda Buck
- [1]
|
||||||||
|
|||||||||||||||||||||||
- 1947 births
- Living people
- American neuroscientists
- Columbia University alumni
- Nobel laureates in Physiology or Medicine
- American Nobel laureates
- University of Washington alumni
- University of Washington faculty
- Harvard University staff
- Howard Hughes Medical Investigators
- Women scientists
- Women neuroscientists
- Fellows of the American Academy of Arts and Sciences
- Fellows of the American Association for the Advancement of Science
- Members of the United States National Academy of Sciences
- People from Seattle, Washington
- University of Texas Southwestern Medical Center alumni
- Women Nobel laureates
