Lipoflavonoid

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Lipoflavonoid (or Lipo-flavonoid) is a proprietary, over-the-counter, dietary supplement formula created in 1961, by NUMARK Laboratories, which is claimed by the manufacturer to improve circulation in the inner ear,[1] as a means of combatting tinnitus (ringing in the ears).[2] While it has not been expressly approved by the Food and Drug Administration for this purpose, the formulation and package claims comply with FDA regulations for dietary supplements.[3]

Lipoflavonoid is currently being marketed on the Internet and in television commercials specifically to relieve tinnitus.[4] Clinical studies of the product appear in refereed journals address its use in treating sensorineural hearing loss,[5] both inclusive of and exclusive of Meniere’s disease,[6] of which tinnitus is a recognized symptom.[7] While a Mayo Clinic article on tinnitus states there is "little evidence that common alternative medicine treatments for tinnitus," the same article goes on to specifically name Lipoflavonoid as an alternative therapy.[8] In the early 1960s, the Audiology Center of Walter Reed Hospital conducted a double-blind, placebo-controlled study of the effects of the lemon bioflavonoid active ingredient of Lipo-flavonoid on patients with hearing loss not associated with Meniere's Disease. None of the study participants who took bioflavonoid showed improvement of hearing as measured by pure tone audiometry.[6]

Composition and effects[edit]

Lipoflavonoid is sold as a dietary supplement. It is composed of eriodictyol glycoside (a bioflavonoid found naturally in the peel of lemons) and the following vitamins: vitamin B6 and B12 (B complex), vitamin C, niacin, riboflavin, thiamine, choline, inositol, and pantothenic acid.[9]

There is significant anecdotal evidence of the efficacy of Lipoflavonoid in relieving the symptoms of tinnitus by consumers,[10][11] in addition to the recommendations of the product some physicians, including Dr. Peter Gott.[12][13]

References[edit]

  1. ^ "U.S. Food and Drug Administration. Archive of 21CFR 101.93 compliance notification". Retrieved 2014-04-04. "Lipo-flavonoid provides nutritional support to improve circulation in the inner ear." 
  2. ^ "About Lipo-flavonoid: References", manufacturers website
  3. ^ "U.S. Food and Drug Administration, Dietary Supplements". Retrieved 2014-04-04. "Although dietary supplement manufacturers must register their facilities with FDA, they are not required to get FDA approval before producing or selling dietary supplements." 
  4. ^ "Lipo-flavonoid Testimonials and Reviews", manufacturers website
  5. ^ "About Lipo-flavonoid: References", manufacturers website
  6. ^ a b "Bioflavonoid Therapy in Sensorineural Hearing Loss: A Double-Blind Study", James E. Creston, Marion R. Gillespie, Alvin L. Larson, Arch Otolaryngol. 1965;82(2):159-165
  7. ^ "Mayo Clinic. Diseases and Conditions. Meniere's disease". Retrieved 2014-04-04. "Meniere's disease is a disorder of the inner ear that causes spontaneous…ringing in the ear (tinnitus)… in your ear." 
  8. ^ "Tinnitus: Alternative Medicine"
  9. ^ "About Lipo-flavonoid: Lipo-flavonoid-Plus Ingredients", manufacturers website
  10. ^ "WebMD. User Reviews & Ratings - Lipo-Flavonoid Plus Oral". Retrieved 2014-04-04. "3 months in my ringing was reduced 85% to 90% and has maintained that level for the last 10+ years," "The best two weeks of the past 3 years praise God," "After taking this supplement for a few months the ringing as subsided by 90+ per cent." 
  11. ^ "Amazon.com. Customer Reviews - DSE Healthcare Solutions - LipoFlavonoid Plus Extra Strength Unique Ear Health Formula - 100 Caplets". Retrieved 2014-04-04. "For me, this product has been a true miracle," "After about 3 weeks the buzzing in my ear was cut in half ," "I used this product for one month and it works." 
  12. ^ Gott, Peter. "Man with tinnitus wants relief". Retrieved 2014-04-04. "Lipoflavonoid is an OTC ear health formula that has received very good results. " 
  13. ^ Gott, Peter. "Turn off the ringer in your ears with Lipo-Flavonoid". Retrieved 2014-04-04. "Some forms of tinnitus respond to Lipo-Flavonoid, which is safe, and, to my knowledge, causes no adverse effects."