Lipothrixviridae
| Lipothrixviridae | |
|---|---|
| Virus classification | |
| Group: | Group I (dsDNA) |
| Order: | Ligamenvirales |
| Family: | Lipothrixviridae |
| Genera | |
|
Alphalipothrixvirus |
|
The Lipothrixviridae family consists of a family of viruses that infect archaea.[1][2]
Contents |
[edit] Taxonomy
These viruses share characteristics from the Rudiviridae family and both have are filamentous viruses with linear dsDNA genomes that infect thermophilic archaea in the kingdom Crenarchaeota[3].
There are four genera in this family: Alphalipothrixvirus, Betalipothrixvirus, Gammalipothrixvirus and Deltalipothrixvirus.[4] They are classified into genera based on their genomic properties and on the diversity of their terminal appendages, which are involved in host cell recognition.
In the genus Gammalipothrixvirus claw-like structures are found at either end of the viron.
[edit] Virology
The viruses are enveloped and rod-shaped. The capsid varies considerably in length - 410-1950 nanometers (nm) - and is 24-38 nm in diameter. The envelope has a bilayer structure and include glycolipids and phospholipids, di-phytanyl tetraethers lipids. The phosphate residues of phospholipids are oriented towards the inside of the viron; the glycosyl residues of glycolipids are oriented towards the outside of the viron.
From either end of the viron are protrusions extending from the core through the envelope. The capsid itself is elongated and exhibits helical symmetry. The core itself is helical.
There two major capsid proteins (MCP1 and MCP2). The basic MCP1 protein forms a core around which the genomic dsDNA is wrapped, whereas MCP2 interacts with the genome with its basic N-terminal region and the hydrophilic C-terminal domain is embedded into the lipid envelope
[edit] References
- ^ Arnold, H.P., Zillig, W., Ziese, U., Holz, I., Crosby, M., Utterback, T., Weidmann, J.F., Kristjanson, J.K., Klenk, H.P., Nelson, K.E. and Fraser, C.M. (2000). A novel lipothrixvirus, SIFV, of the extremely thermophilic crenarchaeon Sulfolobus. Virology, 267, 252-266.
- ^ Janekovic, D., Wunderl S, Holz I, Zillig W, Gierl A, Neumann H (1983) TTV1, TTV2 and TTV3, a family of viruses of the extremely thermophilic anaerobic, sulphur reducing, archaeabacterium Thermoproteus tenax. Mol. Gen. Genet. 19239-19245
- ^ Bettstetter, M., Peng, X., Garrett, R.A. and Prangishvili, D. (2003). AFV-1, a novel virus infecting hyperthermophilic archaea of the genus Acidianus. Virology, 315, 68-79.
- ^ Häring M, Vestergaard G, Brügger K, Rachel R, Garrett RA, Prangishvili D (2005) Structure and genome organization of AFV2, a novel archaeal lipothrixvirus with unusual terminal and core structures. J Bacteriol 187(11): 3855–3858 doi: 10.1128/JB.187.11.3855-3858.2005
[edit] External links
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