Lipotropin is a hormone produced by the cleavage of pro-opiomelanocortin (POMC). The anterior pituitary gland produces the pro-hormone POMC, which undergoes cleavage to adrenocorticotropin (ACTH) and β-lipotropin (β-LPH).
β-Lipotropin [ edit ]
β-Lipotropin is a 90-
amino acid polypeptide that is the carboxy-terminal fragment of POMC.
melanocytes to produce melanin, and can also be cleaved into smaller peptides. In humans, γ-lipotropin, α-MSH, β-MSH, γ-MSH, α-endorphin, β-endorphin, γ-endorphin, and met-enkephalin are all possible fragments of β-lipotropin. [1 ]
β-Lipotropin also performs lipid-mobilizing functions such as
lipolysis and steroidogenesis.
γ-Lipotropin [ edit ]
γ-lipotropin is the
amino-terminal peptide fragment of β-lipotropin. In humans, it has 56 amino acids.
Use in sport [ edit ]
Lipotropin has also, under its alternate name AOD-9604 (Anti-Obesity Drug-9604),
been connected with controversies in [2 ] Australian Rules Football. Allegations have arisen around the use of the drug and its administration to players of the Essendon Football Club as a supplement, including weekly administration to players in the 2012 season. The matters are currently under investigation due to the relationship between Lipotropin and growth hormones, as noted by club medical staff. [3 ]
References [ edit ]
^ Joachim Spiess, Charles D. Mount, Wendell E. Nicholson, David N. Orth (1982), "NH2-Terminal amino acid sequence and peptide mapping of purified human β-lipotropin: Comparison with previously proposed sequences", Proc. Natl. Acad. Sci. USA 79 (16): 5071–5, Bibcode: 1982PNAS...79.5071S, doi: 10.1073/pnas.79.16.5071, PMC 346829, PMID 6956916
^ Peptides Direct information page, accessed 26 August 2013
^ AFL Statement of Charges against James Hird and Essendon Football Club, accessed 26 August 2013 
External links [ edit ]
B trdu: iter ( nrpl/ grfl/ cytl/ horl), csrc ( lgic, enzr, gprc, igsr, intg, nrpr/ grfr/ cytr), itra ( adap, gbpr, mapk), calc, lipd; path ( hedp, wntp, tgfp+ mapp, notp, jakp, fsap, hipp, tlrp)